Paul A. Insel
机构: Professor of Pharmacology and Medicine, University of California San Diegoa la
主页: ucsd.edu
每年引用次数
引用次数
引用: 45,285
H-指数: 115
I10-指数 : 387
出版物: 993
Transient high affinity binding of agonists to beta- -adrenergic receptors (betaar) of s49 cells. Abstr.
A M Koachman , H J Motulsky , L C Mahan , P A Insel
1875
1983
Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2.
M A Balboa , P A Insel , B L Firestein , C Godson
Journal of Biological Chemistry 269 ( 14) 10511 -10516
121
1994
Alterations in the beta-adrenergic receptor-camp pathway in s49 cells grown in serum and serum-free medium. Abstr.
F J Darfler , P A Insel
253
1981
Inhibition of ornithine decarboxylase by agents increasing camp in s49 cells. Abstr.
P A Insel , J M Honeysett
869
1980
Cell cycle-specific regulation of beta-adrenergic receptors and cyclic amp accumulation in s49 lymphoma cells. Abstr.
L C Mahan , P A Insel
253
1981
Decreased beta 2-adrenergic receptor mRNA expression in receptor-deficient S49 lymphoma cells.
P A Insel , R J Hughes , J M Allen , M J Howard
Molecular Pharmacology 40 ( 6) 974 -979
6
1991
Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. I. Receptor metabolism after irreversible blockade of receptors and in cells traversing the cell division cycle.
P A Insel , L C Mahan
Molecular Pharmacology 29 ( 1) 7 -15
22
1986
[3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site.
MARTIN C Michel , OTTO-ERICH Brodde , BERND Schnepel , JOHANNES Behrendt
Molecular Pharmacology 35 ( 3) 324 -330
169
1989
Characterization of the alpha-1 adrenoceptor subtype mediating [3H]-arachidonic acid release and calcium mobilization in Madin-Darby canine kidney cells.
P A Insel , D E Clarke , D A Craig , J A Camacho
Journal of Pharmacology and Experimental Therapeutics 268 ( 3) 1588 -1596
5
1994
Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions.
D Bernstein , S R Post , P A Insel , K H Desai
Journal of Pharmacology and Experimental Therapeutics 274 ( 2) 937 -942
26
1995
Agonist-mediated regulation of alpha 1- and beta 2-adrenergic receptor metabolism in a muscle cell line, BC3H-1.
P A Insel , R J Hughes
Molecular Pharmacology 29 ( 6) 521 -530
34
1986
Selective blockade and recovery of cell surface alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells. Studies with the irreversible antagonist benextramine.
P A Insel , W R Strickland , R M McKernan
Molecular Pharmacology 33 ( 1) 51 -57
5
1988
Characterization of a bromoacetylated derivative of pindolol as a high affinity, irreversible beta adrenergic antagonist in cultured cells.
H J Motulsky , P A Insel , J R Jasper
Journal of Pharmacology and Experimental Therapeutics 244 ( 3) 820 -824
8
1988
Desensitization of epinephrine-initiated platelet aggregation does not alter binding to the alpha 2-adrenergic receptor or receptor coupling to adenylate cyclase.
S J Shattil , H J Motulsky , P A Insel , N Ferry
Molecular Pharmacology 29 ( 1) 1 -6
38
1986
Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex. Differential regulation of alpha 1- and alpha 2-adrenergic receptors by guanyl nucleotides and Na.
P A Insel , M D Snavely
Molecular Pharmacology 22 ( 3) 532 -546
97
1982
Interactions of amiloride with alpha- and beta-adrenergic receptors: amiloride reveals an allosteric site on alpha 2-adrenergic receptors.
H J Motulsky , P A Insel , R J Hughes , M J Howard
Molecular Pharmacology 32 ( 1) 53 -58
40
1987
Renal alpha 1-adrenergic receptor subtypes: MDCK-D1 cells, but not rat cortical membranes possess a single population of receptors.
P A Insel , K Bell , K Klijn , S R Slivka
Molecular Pharmacology 39 ( 3) 407 -413
21
1991
Use of 1-deoxymannojirimycin to show that complex oligosaccharides regulate cellular distribution of the alpha 1-adrenergic receptor glycoprotein in BC3H1 muscle cells.
P A Insel , B I Terman
Molecular Pharmacology 34 ( 1) 8 -14
3
1988
Characterization of coexisting alpha 1- and beta 2-adrenergic receptors on a cloned muscle cell line, BC3H-1.
P Taylor , P A Insel , R D Brown , R J Hughes
Molecular Pharmacology 22 ( 2) 258 -266
31
1982
Apparent "down-regulation" of human platelet alpha 2-adrenergic receptors is due to retained agonist.
H J Motulsky , P A Insel , J S Karliner
Molecular Pharmacology 21 ( 1) 36 -43
58
1982