Tuomas Knowles
机构: Professor of Physical Chemistry and Biophysics, University of Cambridge
主页: cam.ac.uk
每年引用次数
引用次数
引用: 40,518
H-指数: 98
I10-指数 : 363
出版物: 721
Fluctuations in the Kinetics of Linear Protein Self-Assembly
Thomas CT Michaels , Alexander J Dear , Julius B Kirkegaard , Kadi L Saar
Physical Review Letters 116 ( 25) 258103 -258103
24
2016
Hamiltonian Dynamics of Protein Filament Formation.
Thomas C. T. Michaels , Samuel I. A. Cohen , Michele Vendruscolo , Christopher M. Dobson
Physical Review Letters 116 ( 3) 038101 -038101
23
2016
Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
Erik van Dijk , Patrick Varilly , Tuomas P. J. Knowles , Daan Frenkel
Physical Review Letters 116 ( 7) 078101 -078101
22
2016
Quantifying Measurement Fluctuations from Stochastic Surface Processes on Sensors with Heterogeneous Sensitivity
Jérôme Charmet , Thomas C. T. Michaels , Ronan Daly , Abhinav Prasad
Physical review applied 5 ( 6) 064016
3
2016
Role of Elongation and Secondary Pathways in S6 Amyloid Fibril Growth
Nikolai Lorenzen , Samuel I.A. Cohen , Søren B. Nielsen , Therese W. Herling
Biophysical Journal 102 ( 9) 2167 -2175
30
2012
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
Vaishali Kakkar , Cecilia Månsson , Eduardo P De Mattos , Steven Bergink
Molecular Cell 62 ( 2) 272 -283
79
2016
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation.
Sarah L Shammas , Christopher A Waudby , Shuyu Wang , Alexander K Buell
Biophysical Journal 101 ( 7) 1681 -1689
114
2011
Perturbation of the Stability of Amyloid Fibrils through Alteration of Electrostatic Interactions
Sarah L. Shammas , Tuomas P.J. Knowles , Andrew J. Baldwin , Cait E. MacPhee
Biophysical Journal 100 ( 11) 2783 -2791
140
2011
Direct observation of the interconversion of normal and toxic forms of α-synuclein.
Nunilo Cremades , Samuel I.A. Cohen , Emma Deas , Andrey Y. Abramov
Cell 149 ( 5) 1048 -1059
515
2012
A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions
Therese W. Herling , David J. O’Connell , Mikael C. Bauer , Jonas Persson
Biophysical Journal 110 ( 9) 1957 -1966
17
2016
The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.
T P J Knowles , G Meisl , A Goriely , T B Thompson
Journal of Chemical Physics 154 ( 12) 125101 -125101
2021
Imaging Alzheimer's disease-related protein aggregates in human cells using a selenium label
E K McGuire , M Motskin , T P J Knowles , C M Dobson
Journal of Physics: Conference Series 241 ( 1) 012020
1
2010
Role of intermolecular forces in defining material properties of protein nanofibrils.
T. P. Knowles , A. W. Fitzpatrick , S. Meehan , H. R. Mott
Science 318 ( 5858) 1900 -1903
791
2007
Physical determinants of the self-replication of protein fibrils
Anđela Šarić , Alexander K. Buell , Georg Meisl , Thomas C. T. Michaels
Nature Physics 12 ( 9) 874 -880
94
2016
Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics
Cristina Bertulli , Magda Gerigk , Nicholas Piano , Ye Liu
Scientific Reports 8 ( 1) 12480 -12480
13
2018
Biomembranes in bioelectronic sensing
AK Jayaram , Anna-Maria Pappa , S Ghosh , ZA Manzer
Trends in Biotechnology 40 ( 1) 107 -123
8
2022
Mechanisms of Amyloid-beta 42 oligomer formation from kinetic analysis
TC Michaels , A Saric , HW Lazell , P Arosio
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 46 S240 -S240
2017
Rapid sizing of proteins in complex solutions
P Arosio , T Muller , L Rajah , EV Yates
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44 S49 -S49
2015
New insights into the mechanism of amyloid formation by alpha-synuclein
AK Buell , C Galvagnion , CM Dobson , TPJ Knowles
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44 S100 -S100
2015
An algorithm and experimental protocol to obtain the kinetic parameters of fibrillar growth from a first-principles general model of breakable filament assembly
SI Cohen , M Sandal , L Rajah , CM Dobson
FEBS JOURNAL 277 257 -257
2010