Eugene Khandros
机构: Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
每年引用次数
引用次数
引用: 1,589
H-指数: 19
I10-指数 : 22
出版物: 57
Unc 51–like autophagy-activating kinase (ULK1) mediates clearance of free α-globin in β-thalassemia
Christophe Lechauve , Julia Keith , Eugene Khandros , Stephanie Fowler
bioRxiv 454652
2018
Heterogeneity of fetal hemoglobin production in adult red blood cells.
Eugene Khandros , Gerd A. Blobel
Current Opinion in Hematology 28 ( 3) 164 -170
2021
Ulk1 Kinase Mediates Clearance of Free α-Globin in β-Thalassemia
Christophe Lechauve , Eugene Khandros , Christopher Thom , Abdullah Freiwan
Blood 130 285 -285
2017
Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein Spop As a Novel Repressor of Fetal Hemoglobin
Xianjiang Lan , Eugene Khandros , Jeremy D. Grevet , Scott A. Peslak
Blood 132 414 -414
2
2018
A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells
Eugene Khandros , Peng Huang , Scott A. Peslak , Malini Sharma
Blood 136 16 -17
2020
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia
Eugene Khandros , Christopher S. Thom , Janine D'Souza , Mitchell J. Weiss
Blood 119 ( 22) 5265 -5275
85
2012
The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
Zhiying Zou , David R. Enis , Hung Bui , Eugene Khandros
Blood 121 ( 16) 3228 -3236
19
2013
The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells.
Xianjiang Lan , Eugene Khandros , Peng Huang , Scott A. Peslak
Blood Advances 3 ( 10) 1586 -1597
10
2019
HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation.
Scott A. Peslak , Eugene Khandros , Peng Huang , Xianjiang Lan
Blood Advances 4 ( 18) 4560 -4572
2
2020
Trim58 Is a Putative E3 Ubiquitin Ligase That Functions in Late Stage Erythropoiesis
Christopher S. Thom , Eugene Khandros , Yu Yao , Jenna M. Nickas
Blood 120 ( 21) 83 -83
2
2012
Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts.
Eugene Khandros , Peng Huang , Scott A. Peslak , Malini Sharma
Blood 135 ( 22) 1957 -1968
7
2020
The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression
Peng Huang , Scott A. Peslak , Xianjiang Lan , Eugene Khandros
Blood 135 ( 24) 2121 -2132
35
2020
A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex
Sathyanarayanan V. Puthanveettil , Francisco J. Monje , Maria Concetta Miniaci , Yun-Beom Choi
Cell 135 ( 5) 960 -973
72
2008
Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia.
Md Nasimuzzaman , Eugene Khandros , Xiaomei Wang , Yi Kong
American Journal of Hematology 85 ( 10) 820 -822
14
2010
Trim58 Degrades Dynein and Regulates Terminal Erythropoiesis
Christopher S. Thom , Elizabeth A. Traxler , Eugene Khandros , Jenna M. Nickas
Developmental Cell 30 ( 6) 688 -700
53
2014
Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.
Todd L. Mollan , Eugene Khandros , Mitchell J. Weiss , John S. Olson
Journal of Biological Chemistry 287 ( 14) 11338 -11350
17
2012
Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.
Eugene Khandros , Todd L. Mollan , Xiang Yu , Xiaomei Wang
Journal of Biological Chemistry 287 ( 14) 11325 -11337
16
2012
α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-Oxygen Bond *
Claire F. Dickson , Anne M. Rich , William M. H. D'Avigdor , Daniel A. T. Collins
Journal of Biological Chemistry 288 ( 27) 19986 -20001
9
2013
Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing
Peng Huang , Scott A. Peslak , Xianjiang Lan , Eugene Khandros
Blood 134 814 -814
2019
Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells
Eugene Khandros , Peng Huang , Scott A. Peslak , Belinda Giardine
Blood 134 981 -981
2019