P5090Sortilin is a key driver of fibrocalcific aortic valve disease

F Schlotter , C Goettsch , M A Rogers , J D Hutcheson
European Heart Journal 39

2018
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.

Rafael Kramann , Claudia Goettsch , Janewit Wongboonsin , Hiroshi Iwata
Cell Stem Cell 19 ( 5) 628 -642

262
2016
Antagonism of the 5-HT2B receptor prevents TGF-beta1 effects in aortic valve fibroblasts

Vincent Setola , W. David Merryman , Joshua D Hutcheson , Bryan L. Roth
The FASEB Journal 25

1
2011
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.

Andrew K Mlynarchik , Arda Halu , Elena Aikawa , Elena Aikawa
Cardiovascular Research

2
2021
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model.

Paolo Bergese , Paolo Bergese , Fabrizio Buffolo , Elena Aikawa
Proceedings of the National Academy of Sciences of the United States of America 118 ( 14)

2021
Oscillatory Fluid-Induced Mechanobiology in Heart Valves with Parallels to the Vasculature

Chia-Pei Denise Hsu , Joshua D Hutcheson , Sharan Ramaswamy
Vascular biology (Bristol, England) 2 ( 1)

2020
The developmental origin of calcific aortic stenosis

Elena Aikawa , Joshua D Hutcheson
New England Journal of Medicine 386 ( 14) 1372 -1374

6
2022
The time-dependent role of bisphosphonates on atherosclerotic plaque calcification

Amirala Bakhshian Nik , Hooi Hooi Ng , Manuel Garcia Russo , Francesco Iacoviello
Journal of Cardiovascular Development and Disease 9 ( 6) 168

2
2022
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity

Farwah Iqbal , Florian Schlotter , Dakota Becker-Greene , Adrien Lupieri
European Heart Journal 44 ( 10) 885 -898

2
2023
Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease

Florian Schlotter , Arda Halu , Shinji Goto , Mark C Blaser
Arteriosclerosis, Thrombosis, and Vascular Biology 38 ( Suppl_1) A228 -A228

1
2018
Membrane remodeling of human-engineered cardiac tissue by chronic electric stimulation

Alberto Sesena-Rubfiaro , Navin J Prajapati , Lia Paolino , Lihua Lou
ACS Biomaterials Science & Engineering 9 ( 3) 1644 -1655

6
2023
Pigmentation affects elastic fiber patterning and biomechanical behavior of the murine aortic valve

Sana Nasim , Popular Panday , Rosemeire M Kanashiro-Takeuchi , Jin He
Frontiers in Cardiovascular Medicine 1753 -1753

1
2021
Highly selective PPARα (peroxisome proliferator‐activated receptor α) agonist Pemafibrate inhibits stent inflammation and restenosis assessed by multimodality molecular‐microstructural imaging

Hiroshi Iwata , Eric A Osborn , Giovanni J Ughi , Kentaro Murakami
Journal of the American Heart Association 10 ( 20) e020834 -e020834

10
2021
Dynamin-Related Protein 1 Regulates Proteostasis and Proprotein Convertase Subtilisin/Kexin Type 9 Secretion

Maximillian A Rogers , Joshua D Hutcheson , Claudia Goettsch , Arda Halu
Arteriosclerosis, Thrombosis, and Vascular Biology 38 ( Suppl_1) A175 -A175

2018
Sortilin 1 Promotes Matrix Vesicle-Mediated Vascular Microcalcification via Rab11 Trafficking and C-Terminal Phosphorylation

Claudia Goettsch , Joshua D Hutcheson , Masanori Aikawa , Sasha Singh
Arteriosclerosis, Thrombosis, and Vascular Biology 34 ( suppl_1) A51 -A51

1
2014
Cardiovascular calcification and bone mineralization

Elena Aikawa , Joshua D Hutcheson ,
Springer Nature

5
2020
Epidermal growth factor receptor inhibition prevents caveolin-1-dependent calcifying extracellular vesicle biogenesis

Amirala Bakhshian Nik , Hooi Hooi Ng , Patrick Sun , Francesco Iacoviello
bioRxiv

2
2022
Inter-Organ Communication in Homeostasis and Disease: Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis

Amirala Bakhshian Nik , Hooi Hooi Ng , Sophie K Ashbrook , Patrick Sun
American Journal of Physiology-Heart and Circulatory Physiology 324 ( 4) H553 -H553

2023
Freeze casting to engineer gradient porosity in hydroxyapatite-boron nitride nanotube composite scaffold for improved compressive strength and osteogenic potential

Tony Thomas , Amirala Bakhshiannik , Pranjal Nautiyal , Joshua D Hutcheson
Journal of the Mechanical Behavior of Biomedical Materials 150 106283 -106283

1
2024