Thomas Binz
机构: Medizinische Hochschule Hannover
每年引用次数
引用次数
引用: 14,054
H-指数: 56
I10-指数 : 88
出版物: 161
Characterising and exploiting the binding of botulinum neurotoxins to their neuronal receptors
Rummel Andreas , Karnath Tino , Häfner Kirstin , Mahrhold Stefan
Toxicon 51 4
2008
Substrate recognition mechanism of VAMP/synaptobrevin cleaving clostridial neurotoxins
Sikorra Stefan , Henke Tina , Galli Thierry , Binz Thomas
Toxicon 51 7
2008
Inhibition of exocytotic activity in human mast cell line 1 by clostridial neurotoxin light chains
Balletta Andrea , Mahrhold Stefan , Schlesinger Friedrich , Rummel Andreas
Toxicon 51 45
2008
Botulinum Neurotoxin G Binds Synaptotagmin-II in a Mode Similar to That of Serotype B: Tyrosine 1186 and Lysine 1191 Cause Its Lower Affinity
Willjes Gesche , Mahrhold Stefan , Strotmeier Jasmin , Eichner Timo
2013
DUPLICATION OF NEURONAL BINDING DOMAINS DERIVED FROM CLOSTRIDIAL NEUROTOXINS GREATLY ENHANCE INTRANEURONAL DELIVERY OF THERAPEUTICS.
Charlotte Leesea , Maria Maiarub , Rebecca Bresnahana , Thomas Binzc
2018
Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant.
Stefan Sikorra , Sarah Donald , Mark Elliott , Susan Schwede
Toxins 12 ( 12) 804
2020
Clostridial Neurotoxins: Mechanism of SNARE Cleavage and Outlook on Potential Substrate Specificity Reengineering
Thomas Binz , Stefan Sikorra , Stefan Mahrhold
Toxins 2 ( 4) 665 -682
53
2010
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
Stefan Sikorra , Martin Skiba , Martin Dorner , Jasmin Weisemann
Toxins 10 ( 8) 311
1
2018
Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity.
Tao Xu , Thomas Binz , Heiner Niemann , Erwin Neher
Nature Neuroscience 1 ( 3) 192 -200
308
1998
Cell entry strategy of clostridial neurotoxins
Thomas Binz , Andreas Rummel
Journal of Neurochemistry 109 ( 6) 1584 -1595
145
2009
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation‐dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
Andreas Rummel , Kirstin Häfner , Stefan Mahrhold , Natallia Darashchonak
Journal of Neurochemistry 110 ( 6) 1942 -1954
179
2009
Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization.
Thomas Binz , Steffen Bade , Andreas Rummel , Astrid Kollewe
Biochemistry 41 ( 6) 1717 -1723
92
2002
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves
Stefan Mahrhold , Andreas Rummel , Hans Bigalke , Bazbek Davletov
FEBS Letters 580 ( 8) 2011 -2014
287
2006
Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins
Régis Nouvian , Jakob Neef , Anna V Bulankina , Ellen Reisinger
Nature Neuroscience 14 ( 4) 411 -413
88
2011
Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells
Jason Arsenault , Sabine A. G. Cuijpers , Enrico Ferrari , Dhevahi Niranjan
Journal of Neurochemistry 129 ( 5) 781 -791
13
2014
Nucleotide sequence of Clostridium botulinum C1 neurotoxin
Daniel Hauser , Melvin W. Eklund , Hisao Kurazono , Thomas Binz
Nucleic Acids Research 18 ( 16) 4924 -4924
91
1990
Nucleotide sequence of the gene encoding Clostridium botulinum neurotoxin type D.
Thomas Binz , Hisao Kurazono , Michel R. Popoff , Melvin W. Eklund
Nucleic Acids Research 18 ( 18) 5556 -5556
100
1990
Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism.
Giulia Zanetti , Domenico Azarnia Tehran , Marcon Pirazzini , Thomas Binz
Biochemical Pharmacology 98 ( 3) 522 -530
26
2015
Erratum to "Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism" [Biochem. Pharmacol. 98 (2015) 522-530].
Giulia Zanetti , Domenico Azarnia Tehran , Marco Pirazzini , Thomas Binz
Biochemical Pharmacology 115 152
2016