Luk H. Vandenberghe, Ph.D.
机构: Grousbeck Family Chair in Gene Therapy, Associate Professor of Ophthalmology, Harvard University
主页: vdb-lab.org
每年引用次数
引用次数
引用: 16,542
H-指数: 61
I10-指数 : 123
出版物: 359
Adeno_Associated Virus (AAV)-Mediated Transduction of the Macula in Non-Human Primates (NHPs): Cell-Specificity, Stability and Safety of Transduction After Subretinal Delivery of AAV2 and AAV2/8 Vectors
R. Calcedo , A. M. Maguire , J. Bennett , P. Bell
Investigative Ophthalmology & Visual Science 48 ( 13) 1983 -1983
1
2007
Anc80L65 results in more widespread gene transfer in the CNS of non-human primates compared to AAV9
LM Stanek , R Calcedo , B Mastis , D Sanders
HUMAN GENE THERAPY 32 ( 19-20) A46 -A46
2021
Divergent AAV serotypes demonstrate an alternate, AAVR independent, entry pathway
AM Dudek , S Pillay , AS Puschnik , JE Carette
HUMAN GENE THERAPY 28 ( 12) A9 -A9
2017
Combination of an engineered AAV vector Anc80 and tolerogenic nanoparticles encapsulating rapamycin enables efficient transgene expression in mice with pre-existing neutralizing antibodies and provides a therapeutic benefit in a mouse model of methylmalonic acidemia
Petr O Ilyinskii , Chris Roy , Alicia Michaud , L Li
HUMAN GENE THERAPY 29 ( 12) A168 -A168
2
2018
The combination of ImmTOR with AAV Anc80 is therapeutically effective, safe, and repeatable in mice with methylmalonic acidemia while also being compatible with the low seroprevalence of Anc80 Nabs in the patient population
L Li , RJ Chandler , SS Leung , S Elkins
HUMAN GENE THERAPY 30 ( 11) A151 -A151
2019
Structure-function relationship of the novel non-human primate adeno-associated viruses
LH Vandenberghe , JJ Rux , GP Gao , R Calcedo
Molecular Therapy 7 ( 5) S40 -S40
7
2003
Diversity of latent AAV genomes in non-human primate and human tissues
GP Gao , MR Alvira , Y Lu , LH Vandenberghe
Molecular Therapy 7 ( 5) S158 -S158
7
2003
AAV capsid design: A Goldilocks challenge
S Zolotukhin , LH Vandenberghe
Trends in Molecular Medicine 28 ( 3) 183 -193
37
2022
AAV6. 2: an efficient and safe gene therapy clinical candidate for the treatment of cystic fibrosis airway disease
M Limberis , LH Vandenberghe , L Zhang , RJ Pickles
PEDIATRIC PULMONOLOGY 298 -298
3
2007
AAVCOVID: A single-dose, thermostable COVID-19 vaccine with durable immunogenicity
Nerea Zabaleta , U Bhatt , C Herate , P Maisonnasse
Topics in Antiviral Medicine 93 -94
2022
Single-Dose Optimized AAV-Based COVID-19 Vaccine Elicits Durable and Protective Immunity Against Variants of Concern in Nonhuman Primates
N Zabaleta , U Bhatt , C Herate , P Maisonnasse
Molecular Therapy 530 -531
2022
An AAV-based, room-temperature stable, single dose COVID-19 vaccine
N Zabaleta , U Bhatt , C Herate , W Dai
HUMAN GENE THERAPY 32 ( 19-20) A28 -A28
2021
Combinatorial AAV Capsid Library Enables Multidimensional Study of Vector Biology
E Zinn , C Unzu , PF Schmit , HT Turunen
HUMAN GENE THERAPY 32 ( 19-20) A73 -A74
2021
Combining distinct phenotypes of AAV capsid to simultaneously target and detarget specific tissues in mouse models
K Olivieri , Z Thorpe , S Craig , D Sanders
HUMAN GENE THERAPY 32 ( 19-20) A73 -A73
2021
Cross-packaging control in multiplexed AAV libraries
PF Schmit , E Zinn , J Santos Franceschini , R Estelien
HUMAN GENE THERAPY 29 ( 12) A23 -A24
2018
GALACTOSE DETERMINES ADENO-ASSOCIATED VIRUS SEROTYPE 9'S CONE PHOTORECEPTOR TROPISM
T Marshall , H Turunen , E Plovie , R Chang
JOURNAL OF INVESTIGATIVE MEDICINE 62 ( 1) 208 -208
2014
AAV8-mediated expression of VEGF antagonists in macaque eye: comparison of subretinal vs. intravitreal delivery of vector
MP Limberis , R Xiao , AM Maguire , AM Komaromy
HUMAN GENE THERAPY 22 ( 10) A25 -A25
2011
In silico reconstruction of the viral evolutionary lineage yields a potent gene therapy vector. Cell Rep 12: 1056–1068
E Zinn , S Pacouret , V Khaychuk , HT Turunen
12
2015
Functional CFTR Expression in Cystic Fibrosis Airway Epithelial Cells by AAV6.2-mediated Segmental Trans-splicing
Y Song , H Lou , J Boyer , MP Limberis
Human Gene Therapy 090205172040003
4
2009
Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med 3 (88): 88ra54
LH Vandenberghe , P Bell , AM Maguire , CN Cearley
2011
GuangPing Gao Eva Andres-Mateos Livia S Carvalho Soumitra Roy zeger debyser Jim Riley Veerle Baekelandt Sharif Tabebordbar George Church Graham Simmons Wei Leong Chew Kim Van Vliet, Ph.D. Jean-Marc Taymans Carl June Sadik Kassim Mariacarmela Allocca Ravi A Desai Christopher S. Chen, M.D., Ph.D. Sergey Kryazhimskiy