引用次数
引用: 8,829
H-指数: 49
I10-指数 : 98
出版物: 269
, Combining In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-Based Pharmacokinetics (PBPK) with Drug Related Risk Assessment: Putting Pieces Together for A Priori Assessment of the Likelihood of Cardiotoxicity
M Jamei , A Rostami-Hodjegan , Amin Rostami-Hochaghan , S Polak
In: ACoP, San Diego, USA; 03 Apr 2011-06 Apr 2011; ACoP, San Diego, USA. 2011.
1
2011
Application of physiologically based pharmacokinetic (PBPK) modelling for prediction of complex drug-drug interactions (DDIs) involving OATP1B1-mediated uptake and cytochrome P450 (CYP) metabolism and multiple inhibitors
M Aarabi , M Jamei , A Rostami-Hodjegan , Amin Rostami-Hochaghan
In: ASCPT 2012 Annual Meeting, National Harbour, MA, USA; 12 Mar 2012-17 Mar 2012; ASCPT 2012 Annual Meeting, National Harbour, MA, USA. 2012.
2
2012
Toward Mechanistic Modelinng of Negative Food Effects upon Oral Drug Absorption: Linking In Vivo Dynamic Dilution of Digesta to Viscoscity, Disintegration and Dissolution Rate
M Jamei , DB Turner , A Rostami-Hodjegan , Amin Rostami-Hochaghan
In: 5th World Conference on Drug Absorption and Delivery ; 24 Jun 2013-26 Jun 2013; Uppsala, Sweden. 2013.
2013
A Performance Evaluation of Simcyp Dog- a Fully Mechanistic Physiologically-Based Pharmacokinetic Dog Model ? Based Upon a Variety of Theophylline IV and Oral Formulations
M Jamei , DB Turner , A Rostami-Hodjegan , Amin Rostami-Hochaghan
In: 8th World Congress on Alternatives and Animal use in the Life Sciences, Montreal, Canada ; 21 Aug 2011-25 Aug 2011; 8th World Congress on Alternatives and Animal use in the Life Sciences, Montreal, Canada . 2011.
2011
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Systematic Assessment Based on BCS Attributes and using the ?Advanced Dissolution, Absorption, Absorption (ADAM)? Model
Adam Darwich , M Jamei , S Neuhoff , A Rostami-Hodjegan
In: AAPS Drug Transporters in ADME: From Bench to Bedside, Bethsada MD, USA; 14 Mar 2011-16 Mar 2011; AAPS Drug Transporters in ADME: From Bench to Bedside, Bethsada MD, USA. 2011.
1
2011
Prediction of human intestinal metabolism of CYP3A substrates using the Advanced, Dissolution, Absorption and Metabolism (ADAM) Model
K Rowland-Yeo , M Jamei , A Rostami-Hodjegan , Amin Rostami-Hochaghan
In: 11th Annual Simcyp Consortium Meeting, ; 19 Sep 2010-21 Sep 2010; Sheffield, UK. 2010.
1
2010
Prediction of time-dependent CYP3A4-mediated in vivo drug-drug interactions from in vitro data using biological information on enzyme turnover implemented within a physiologically based model
K Rowland-Yeo , M Jamei , J Yang , GT Tucker
In: ISSX; 12 Oct 2008-16 Oct 2008; San Diego, California. 2008.
2008
Interplay of Transport and Metabolism in the Gut: Predictions of Drug-Drug Interactions using Physiologically Based Pharmacokinetic Modelling
M Jamei , S Neuhoff , A Rostami-Hodjegan , Yeo K Rowland
In: Drug Transporters in ADME: From Bench to Bedside, Bethsada MD, USA; 14 Mar 2011-16 Mar 2011; Drug Transporters in ADME: From Bench to Bedside, Bethsada MD, USA. 2011.
2011
Prediction of Passive Regional Effective Intestinal Permeability in Mouse using ‘MechPeff’: A Mechanistic Model utilizing only Drug Physiochemical Parameters as Inputs
M Jamei , DB Turner , A Rostami-Hodjegan , Amin Rostami-Hochaghan
In: 2013 AAPS Annual Meeting and Exposition; 10 Nov 2013-14 Nov 2013; San Antonio, USA. 2013.
2013
P-gp efflux has no impact on dose proportionalty of Digoxin bioavailability over a dose range of 0.125 to 1.5mg: The outcome of a new PBPK model, that includes the in vitro transporter information is consistent with the clinical observations
M Jamei , S Neuhoff , A Rostami-Hodjegan , Yeo K Rowland
In: 13th Annual Congress for Clinical Pharmacology, Zurich, Switzerland; 20 Oct 2011-22 Oct 2011; 13th Annual Congress for Clinical Pharmacology, Zurich, Switzerland. 2011.
2011
Application of Simcyp to simulate PK as well as response of Nifedipine in Japanese and Caucasian populations
L Gaohua , M Jamei , M Chetty , A. Rostami-Hodjegan
In: 27th JSSX Annual Meeting; 20 Nov 2012-22 Nov 2012; Chiba, Japan. 2012.
2012
An assessment of the OCT2/MATE transporter mediated DDI between metformin and cimetidine using a Mechanistic Kidney model (Mech KiM)
L Almond , L Gaohua , S Neuhoff , HJ Burt
In: AAPS Transporter Workshop; 17 Mar 2013-19 Mar 2013; Bethesda, MD, USA. 2013.
1
2013
Prediction of OAT1B1-Mediated Drug-Drug Interaction Between Repaglinide and Cyclosporine Using Physiologically Based Pharmacokinetic (PBPK) Modelling
M Aarabi , M Jamei , S Neuhoff , A Rostami-Hodjegan
In: AAPS Drug Transporters in ADME: From Bench to Bedside, Bethsada MD, USA; 14 Mar 2011-16 Mar 2011; AAPS Drug Transporters in ADME: From Bench to Bedside, Bethsada MD, USA. 2011.
2011
Application of a PBPK/PD model describing the change in systolic blood pressure following administration of immediate release and controlled release nifedipine formulations
M Jamei , M Chetty , N Patel , G Lu
In: WCoP, Seoul, Korea ; 05 Sep 2012-07 Sep 2012; WCoP, Seoul, Korea . 2012.
2012
A Performance Evaluation of Simcyp Dog- a Fully Mechanistic Physiologically-Based Pharmacokinetic Dog Model ? Based Upon a Variety of Celecoxib IV and Oral Formulations,
A Rostami-Hodjegan , M Martinez , Amin Rostami-Hochaghan , L Antonovic
In: AAPS Annual Meeting and Exposition, Washington DC, USA; 23 Oct 2011-27 Oct 2011; AAPS Annual Meeting and Exposition, Washington DC, USA. 2011.
2
2011
Application of an in silico physiologically based pharmacokinetic model to simulate oral drug bioavailability of Atorvastatin Acid and Cyclosporine post bariatric surgery
M Jamei , DM Ashcroft , H Christensen , A Rostami-Hodjegan
In: ASCPT 2013 Annual Meeting; 05 Mar 2013-09 Mar 2013; Indianapolis, USA. 2013.
2013
PBPK modeling of Negative Food Effects upon Oral Drug Absorption of the BCS Class III Drug Trospium Chloride (TC): Combination of a Dynamic Viscosity-Disintegration Model and the ADAM (Advanced Dissolution, Absorption and Metabolism
Amin Rostami-Hochaghan , A. Turner Db. Rostami-Hodjegan , B Liu , M Jamei
In: 2013 AAPS Annual Meeting and Exposition; 10 Nov 2013-14 Nov 2013; San Antonio, USA. 2013.
2013
Deconvolution Using the ADAM Model: Part 1. Establishing Mechanistic IVIVC for Controlled Release Formulations of the High Extraction BCS Class I Drug Metoprolol: Comparison with Conventional IVIVC Models
M Jamei , D Turner , N Patel , A Rostami-Hodjegan
In: AAPS Annual Meeting and Exposition, Chicago, IL, USA; 14 Oct 2012-18 Oct 2012; AAPS Annual Meeting and Exposition, Chicago, IL, USA. 2012.
2012
Development of a Mechanistic Physiologically Based Pharmacokinetic Model to Assess Oral Drug Bioavailability Post Bariatric Surgery in Morbidly Obese Patients
Adam Darwich , M Jamei , DM Ashcroft , Amin Rostami-Hochaghan
In: ACCP Annual Meeting, San Diego, CA, USA; 23 Sep 2012-25 Sep 2012; ACCP Annual Meeting, San Diego, CA, USA. 2012.
2012
A user-friendly physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain
M Jamei , S Neuhoff , G Lu , A Rostami-Hodjegan
In: 26th JSSX Annual Meeting, Hiroshima, Japan; 16 Nov 2011-18 Nov 2011; 26th JSSX Annual Meeting, Hiroshima, Japan. 2011.
2011
Amin Rostami-Hodjegan Khaled Abduljalil Sebastian Polak DB Turner Adam S Darwich Manoranjenni Chetty Shriram M. Pathak Frederic Y. Bois Ben Small Mohsen Aarabi Jennifer Dressman Klaus Romero Werner Weitschies Jane R Kenny Joachim Brouwers Bart Hens, PharmD, PhD Marilyn N. Martinez Rafael de La Torre Fornell