Mechanism of ion permeation in the glycine receptor and its cation-selective mutations

Megan O'Mara , Peter H. Barry , Shin-Ho Chung , Angelo Keramidas
Biophysical Journal 84 ( 2)

2003
Functional Characteristics of alpha3beta3gamma2 and alpha1beta2gamma2 GABA-A receptors

Angelo Keramidas , Neil Harrison
Biophysical Journal 96 ( 3) 4 -7

2009
A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition

Georg Langlhofer , Natascha Schaefer , Hans M. Maric , Angelo Keramidas
The Journal of Neuroscience 40 ( 25) 4954 -4969

4
2020
Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease

Victoria M. James , Anna Bode , Seo-Kyung Chung , Jennifer L. Gill
Neurobiology of Disease 52 137 -149

43
2013
Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation

Robiul Islam , Angelo Keramidas , Li Xu , Nela Durisic
ACS Chemical Neuroscience 7 ( 12) 1647 -1657

3
2016
Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

Marco C. Inserra , Mathilde R. Israel , Ashlee Caldwell , Joel Castro
Scientific Reports 7 ( 1) 42810 -42810

43
2017
GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

Mohammed Atif , Jennifer J. Smith , Argel Estrada-Mondragon , Xue Xiao
PLOS Pathogens 15 ( 1) e1007570

9
2019
An outline of desensitization in pentameric ligand-gated ion channel receptors

Angelo Keramidas , Joseph W. Lynch
Cellular and Molecular Life Sciences 70 ( 7) 1241 -1253

35
2013
Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy.

Xiumin Chen , Nela Durisic , Joseph W. Lynch , Angelo Keramidas
Neurobiology of Disease 108 213 -224

9
2017
Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

Xiumin Chen , Angelo Keramidas , Robert J. Harvey , Joseph W. Lynch
Neurobiology of Disease 140 104850

1
2020
Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations.

Yan Zhang , Christine L. Dixon , Angelo Keramidas , Joseph W. Lynch
Neuropharmacology 89 391 -397

18
2015
The pre-M1 segment of the α1 subunit is a transduction element in the activation of the GABAA receptor

Angelo Keramidas , Thomas L. Kash , Neil L. Harrison
The Journal of Physiology 575 ( 1) 11 -22

29
2006
Single Channel Analysis of Conductance and Rectification in Cation-selective, Mutant Glycine Receptor Channels

Andrew J. Moorhouse , Angelo Keramidas , Andrey Zaykin , Peter R. Schofield
The Journal of General Physiology 119 ( 5) 411 -425

39
2002
Cation-selective Mutations in the M2 Domain of the Inhibitory Glycine Receptor Channel Reveal Determinants of Ion-Charge Selectivity

Andrew J. Moorhouse , Kerrie D. Pierce , Peter R. Schofield , Peter H. Barry
The Journal of General Physiology 119 ( 5) 393 -410

84
2002
Correlating Structural and Energetic Changes in Glycine Receptor Activation

Suzanne Scott , Joseph W. Lynch , Angelo Keramidas
Journal of Biological Chemistry 290 ( 9) 5621 -5634

19
2015
Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses.

Sophie Leacock , Parnayan Syed , Victoria M. James , Anna Bode
Frontiers in Molecular Neuroscience 11 23 -23

7
2018
SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABAA Receptor γ2 Subunit.

Nela Durisic , Angelo Keramidas , Christine L. Dixon , Joseph W. Lynch
Frontiers in Molecular Neuroscience 11 89 -89

4
2018
The contribution of proline 250 (P-2′) to pore diameter and ion selectivity in the human glycine receptor channel

David J.-S. Lee , Angelo Keramidas , Andrew J. Moorhouse , Peter R. Schofield
Neuroscience Letters 351 ( 3) 196 -200

31
2003
Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.

Christine L Dixon , Neil L Harrison , Joseph W Lynch , Angelo Keramidas
British Journal of Pharmacology 172 ( 14) 3522 -3536

17
2015