Jonathon Winnay

机构: Joslin Diabetes Center, Harvard Medical School

每年引用次数

引用次数

引用: 9,943

H-指数: 30

I10-指数 : 32

出版物: 64

标题

引用次数

年份

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

Jens C Brüning , Jonathon Winnay , Susan Bonner-Weir , Simeon I Taylor
Cell 88 ( 4) 561 -572

483

1997

The phosphoinositide 3-kinase regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signaling

Cullen M. Taniguchi , Jonathon Winnay , Tatsuya Kondo , Roderick T. Bronson
Cancer Research 70 ( 13) 5305 -5315

2010

Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation

Victoria Rotter Sopasakis , Pixu Liu , Ryo Suzuki , Tatsuya Kondo
Cell Metabolism 11 ( 3) 220 -230

158

2010

Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD

Samir Softic , Jeremie Boucher , Marie H. Solheim , Shiho Fujisaka
Diabetes 65 ( 8) 2187 -2200

2016

Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells

Kyoungmin Park , Qian Li , Christian Rask-Madsen , Akira Mima
Molecular and Cellular Biology 33 ( 16) 3227 -3241

2013

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

Hongbin Zhang , Meiping Guan , Kristy L Townsend , Tian Lian Huang
EMBO Reports 16 ( 10) 1378 -1393

138

2015

SHORT Syndrome with Partial Lipodystrophy Due to Impaired Phosphatidylinositol 3 Kinase Signaling

Kishan Kumar Chudasama , Jonathon Winnay , Stefan Johansson , Tor Claudi
American Journal of Human Genetics 93 ( 1) 150 -157

120

2013

The PI3K regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signalling

Cullen M Taniguchi , Jonathon Winnay , Tatsuya Kondo , Roderick T Bronson
Cancer research 70 ( 13) 5305 -5305

2010

A Mouse Model of SHORT Syndrome Exhibits Impaired PI3K Signaling

Marie H Solheim , Jonathon Winnay , Anders Molven , Pal R Njolstad
DIABETES 64 A483 -A483

2015

MicroRNA Determines Brown Fat Differentiation and Thermogenic Function

Hongbin Zhang , Meiping Guan , Tian-Lian Huang , Kristy L Townsend
DIABETES 62 A37 -A37

2013

Serine Phosphorylation (Ser303) of IRS2 by Angiotensin II (AngII) Inhibits Insulin Activation of p-Akt/eNOS in Endothelial Cells

Kyoungmin Park , Qian Li , Christian Rask-Madsen , Akira Mima
DIABETES 61 A414 -A414

2012

Liver-specific insulin receptor knockout mice are severely insulin resistant

J. N. Winnay , M. A. Magnuson , S. E. Curtis , C. Postic
Diabetes 48(SUPPL 1 10

1999

Shox2 is a molecular determinant of depot-specific adipocyte function

K. Y. Lee , Y. Yamamoto , J. Boucher , J. N. Winnay
Proceedings of the National Academy of Sciences of the United States of America 110 ( 28) 11409 -11414

2013

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

R. N. Kulkarni , K. Almind , H. J. Goren , J. N. Winnay
Diabetes 52 ( 6) 1528 -1534

112

2003

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

F. Mauvais-Jarvis , A. Virkamaki , M. D. Michael , J. N. Winnay
Diabetes 49 ( 12) 2126 -2134

2000

p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis

J. N. Winnay , E. Dirice , C. W. Liew , R. N. Kulkarni
Proceedings of the National Academy of Sciences of the United States of America 111 ( 3) 1192 -1197

2014

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.

J C Brüning , J Winnay , B Cheatham , C R Kahn
Molecular and Cellular Biology 17 ( 3) 1513 -1521

191

1997

Insulin-receptor substrate-1 is required for normal myelination

MJ Engleka , F Folli , J Winnay , CR Kahn
Journal of Neurochemistry 66 S20 -S20

1996

Creating polygenic models of insulin resistance and diabetes mellitus.

JC Bruening , J Winnay , S BonnerWeir , D Accili
JOURNAL OF INVESTIGATIVE MEDICINE 44 ( 3) A258 -A258

1996

Mice deficient for the insulin receptor substrate-1 (IRS-1) exhibit an increased susceptibility for obesity and subsequent progression to severe insulin resistance.