Brian Dougherty
机构: Executive Director, AstraZeneca
每年引用次数
引用次数
引用: 37,579
H-指数: 49
I10-指数 : 68
出版物: 146
Molecular characterization of a locus required for hyaluronic acid capsule production in group A streptococci.
B A Dougherty , I van de Rijn
Journal of Experimental Medicine 175 ( 5) 1291 -1299
57
1992
Oral Abstracts 7: RA ClinicalO37. Long-Term Outcomes of Early RA Patients Initiated with Adalimumab Plus Methotrexate Compared with Methotrexate Alone Following a Targeted Treatment Approach
Roy Fleischmann , Ronald F van Vollenhoven , Josef Smolen , Paul Emery
Rheumatology 52
3
2013
AKT Inhibition in Solid Tumors With AKT1 Mutations
David M. Hyman , Lillian M. Smyth , Mark T.A. Donoghue , Shannon N. Westin
Journal of Clinical Oncology 35 ( 20) 2251 -2259
243
2017
Abstract PR05: ERK pathway activation is associated with acquired resistance to AZD9291, a third-generation irreversible inhibitor targeting EGFR sensitizing (EGFRm+) and resistance (T790M) mutations in NSCLC
Cath Eberlein , Katie Al-Kadhimi , Sarah Ross , Henry Brown
Clinical Cancer Research 21
2015
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
Claire M. Fraser , Sherwood Casjens , Wai Mun Huang , Granger G. Sutton
Nature 390 ( 6660) 580 -586
1,792
1997
Model systems in drug discovery: chemical genetics meets genomics.
Pamela M Carroll , Brian Dougherty , Petra Ross-Macdonald , Kailtin Browman
Pharmacology & Therapeutics 99 ( 2) 183 -220
40
2003
Abstract LB-249: Examination of analytical factors impacting concordance of plasma-tumor testing by next-generation sequencing (NGS)
Brian Dougherty , Ambar Ahmed , Tristan Lubinski , Aleksandra Markovets
Cancer Research 77
2
2017
Genes Contributing to Pain Sensitivity in the Normal Population: An Exome Sequencing Study
Frances M. K. Williams , Serena Scollen , Dandan Cao , Yasin Memari
PLoS Genetics 8 ( 12) e1003095
48
2012
Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer (SOC) and a BRCA mutation (BRCAm).
Jonathan A. Ledermann , Philipp Harter , Charlie Gourley , Michael Friedlander
Journal of Clinical Oncology 31 5505 -5505
38
2013
Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M
Kenneth S Thress , Cloud P Paweletz , Enriqueta Felip , Byoung Chul Cho
Nature Medicine 21 ( 6) 560 -562
1,373
2015
Abstract CT217: POLO: Homologous recombination repair gene mutations (HRRm) in metastatic pancreatic cancer (mPaC) tumors
Zhongwu Lai , Talia Golan , Hedy L. Kindler , Brian Dougherty
Cancer Research 80
2020
Abstract LB-123: Analysis of cell-free plasma DNA (cfDNA) identifies 3 molecular subtypes of acquired resistance to AZD9291, a novel EGFR tyrosine kinase inhibitor (TKI), in patients (pts) with advanced lung cancer
Geoffrey R. Oxnard , Kenneth S. Thress , Cloud P. Paweletz , Enriqueta Felip
Cancer Research 75
2015
Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models
Catherine A. Eberlein , Daniel Stetson , Aleksandra A. Markovets , Katherine J. Al-Kadhimi
Cancer Research 75 ( 12) 2489 -2500
285
2015
Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum.
Danielle M Greenawalt , Winnie S Liang , Sakina Saif , Justin Johnson
Oncotarget 8 ( 59) 99237 -99244
11
2017
Analysis of candidate homologous repair deficiency genes in a clinical trial of olaparib in patients (pts) with platinum-sensitive, relapsed serous ovarian cancer (PSR SOC).
Brian Dougherty , Jonathan A. Ledermann , Zhongwu Lai , Jane D Robertson
Journal of Clinical Oncology 32 5536 -5536
2
2014
VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research
Zhongwu Lai , Aleksandra Markovets , Miika Ahdesmaki , Brad Chapman
Nucleic Acids Research 44 ( 11)
615
2016
Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial.
Peter Schmid , Jacinta Abraham , Stephen Chan , Duncan Wheatley
Journal of Clinical Oncology 38 ( 5) 423 -433
207
2020
Olaparib Maintenance Therapy in Patients With Platinum-Sensitive Relapsed Serous Ovarian Cancer
Jonathan Ledermann , Philipp Harter , Charlie Gourley , Michael Friedlander
Obstetrical & Gynecological Survey 69 ( 10) 594 -596
6
2014
Prioritisation of structural variant calls in cancer genomes.
Miika J. Ahdesmäki , Brad A. Chapman , Pablo Cingolani , Oliver Hofmann
PeerJ 5
5
2017
Exploratory biomarker analysis of a phase I study of AZD4547, an inhibitor of fibroblast growth factor receptor (FGFR), in patients with advanced solid tumors.
Elaine Kilgour , David Ferry , Matilde Saggese , Hendrik-Tobias Arkenau
Journal of Clinical Oncology 32 11010 -11010
13
2014