Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival

Tohru Natsume , Atsushi Matsuzawa , Tsuyoshi Udagawa , Takuya Noguchi
Cell Reports 34 ( 1) 108599

2
2021
Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia

Atsushi Matsuzawa , Akira Naganuma , Gi-Wook Hwang , Gi-Wook Hwang
Scientific Reports 11 ( 1) 9832 -9832

2021
trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway.

Atsushi Matsuzawa , Takuya Noguchi , Yusuke Hirata , Ryosuke Matsui
Scientific Reports 11 ( 1) 10350 -10350

2021
The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1.

Atsushi Matsuzawa , Takuya Noguchi , Midori Suzuki , Yusuke Hirata
International Journal of Molecular Sciences 22 ( 11)

2021
Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

Takuya Noguchi , Ken Ishii , Hisashi Fukutomi , Isao Naguro
Journal of Biological Chemistry 283 ( 12) 7657 -7665

204
2008
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.

Manikuntala Kundu , Sushil Kumar Pathak , Kuldeep Kumawat , Sanchita Basu
Nature Immunology 10 ( 8) 918 -926

57
2009
ROS-dependent Activation of ASKI in Inflammatory Signaling

Takuya Noguchi
Journal of Oral Biosciences 50 ( 2) 107 -114

5
2008
174
2005
Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity

Shota Yamauchi , Takuya Noguchi , Hidenori Ichijo
Immune Network 8 ( 1) 1 -6

2008
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1

Kohsuke Takeda , Rieko Shimozono , Takuya Noguchi , Tsuyoshi Umeda
Journal of Biological Chemistry 282 ( 10) 7522 -7531

93
2007
Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis via the P2X7-ROS-ASK1-p38 Axis in Microglial Cell Lines.

Yusuke Hirata , Yuki Nada , Yuto Yamada , Takashi Toyama
Biological & Pharmaceutical Bulletin 43 ( 10) 1562 -1569

9
2020
Stress signaling in cancer

Shiori Murakami , Takuya Noguchi , Kohsuke Takeda , Hidenori Ichijo
Cancer Science 98 ( 10) 1521 -1527

21
2007
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

Atsushi Matsuzawa , Kaoru Saegusa , Takuya Noguchi , Chiharu Sadamitsu
Nature Immunology 6 ( 6) 587 -592

549
2005
Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an Activator of the GAPDH-Siah1 Stress-Signaling Cascade

Carlos A. Tristan , Adriana Ramos , Neelam Shahani , Francesco E. Emiliani
Journal of Biological Chemistry 290 ( 1) 56 -64

22
2015
trans-Fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.

Yusuke Hirata , Miki Takahashi , Yuki Kudoh , Kuniyuki Kano
Journal of Biological Chemistry 292 ( 20) 8174 -8185

25
2017
Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice

Karen Kumakura , Hiroshi Nomura , Takeshi Toyoda , Koichi Hashikawa
Neuroscience Research 66 ( 3) 313 -320

20
2010
trans -Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop

Yusuke Hirata , Aya Inoue , Saki Suzuki , Miki Takahashi
Scientific Reports 10 ( 1) 2743

5
2020
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation

Hayato Nakagawa , Shin Maeda , Yohko Hikiba , Tomoya Ohmae
Gastroenterology 135 ( 4) 1311 -1321

181
2008
Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation.

Takumi Yokosawa , Mayuka Yamada , Takuya Noguchi , Saki Suzuki
The Journal of Antibiotics 72 ( 11) 848 -852

14
2019
The ASK1-MAP kinase pathways in immune and stress responses.

Teruyuki Hayakawa , Atsushi Matsuzawa , Takuya Noguchi , Kohsuke Takeda
Microbes and Infection 8 ( 4) 1098 -1107

77
2006