Continuous flow processing in the pharma industry – an unstoppable trend?

Bernhard Gutmann , Christian Oliver Kappe
European Pharmaceutical Review 20 ( 5) 37 -42

2015
Synthesis and reactions of “biginelli‐compounds”. Part I

Christian Oliver Kappe , Peter Roschger
Journal of Heterocyclic Chemistry 26 ( 1) 55 -64

106
1989
Aniline derivatives from lignin under mild conditions enabled by electrochemistry

Antonio A Castillo‐Garcia , Christian Oliver Kappe , David Cantillo , Katalin Barta
ChemSusChem e202301374 -e202301374

2
2024
Method for preparation of difluoromethylornithine

Bernhard Gutmann , Michael Bersier , Paul Hanselmann , Christian Oliver Kappe

1
2020
Process for preparing btk inhibitors

Stephan Bachmann , Lukas Chytil , Serena Maria Fantasia , Alec Fettes

2024
Process for the manufacture of tetrazole derivatives

Dainis Kaldre , Christian Oliver Kappe , Christian Steffen Moessner , Peter Sagmeister

2024
2023
N-demethylation of morphinan alkaloids

Dominique Roberge , Petteri Elsner , Christian Oliver Kappe , Bernhard Gutmann

2020
Continuous flow synthesis of indoles by Pd-catalyzed deoxygenation of 2-nitrostilbenes with carbon monoxide

Christian Oliver Kappe , Dominique Roberge , Anna Kulesza , Paul Hanselmann
RSC Advanced

Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives

Bernhard Gutmann , David Cantillo , Ulrich Weigl , Douglas Phillip Cox

2017
Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives

Christopher Oliver Kappe , Bernhard Gutmann , Ulrich Weigl , Patrick Egli

1
2019
A Diversity‐Oriented, Microwave‐Assisted Synthesis of 4‐oxo and 4‐chloropyrido[2,3‐d]pyrimidin‐7(8H)‐ones

N. Mont , L. Fernández-Megido , J. Teixidó , C. O. Kappe
Qsar & Combinatorial Science 23 ( 10) 836 -849

12
2004
Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids

Harald F. Hofbauer , Florian H. Schopf , Hannes Schleifer , Oskar L. Knittelfelder
Developmental Cell 29 ( 6) 729 -739

63
2014
High-Speed Couplings and Cleavages in Microwave-Heated, Solid-Phase Reactions at High Temperatures

Alexander Stadler , C. Oliver Kappe
European Journal of Organic Chemistry 2001 ( 5) 919 -925

116
2001
Preparation and Chemistry of an Unexpectedly Stable α‐Oxoketene−Pyridine Zwitterion, 2,2‐Bis(tert‐butylcarbonyl)‐1‐[4‐(dimethylamino)pyridinio]ethen‐1‐olate

Gert Kollenz , Susanne Holzer , C. Oliver Kappe , Turkaram S. Dalvi
European Journal of Organic Chemistry 2001 ( 7) 1315 -1322

17
2001
Flow Technology for Telescoped Generation, Lithiation and Electrophilic (C3) Functionalization of Highly Strained 1‐Azabicyclo[1.1.0]butanes

Pantaleo Musci , Timo von Keutz , Ferdinand Belaj , Leonardo Degennaro
Angewandte Chemie 60 ( 12) 6395 -6399

5
2021