Isoindolinone based inhibitors of the MDM2-p53 protein-protein interaction

SJ Kemp , IR Hardcastle , SU Ahmed , NA Atatreh
Abstracts of Papers of the American Chemical Society

2005
Synthesis of the Novel Difluoro analogue of UCS15A and its Evaluation With Src

J. Barraclough , S Freeman , C Dive , Richard Bryce
In: Contribution to the Bath Medicinal Chemistry Conference; 2006.

2006
Inhibition of Src for potential use in cancer chemotherapy

C Stojkoski , J. Barraclough , G Booker , S Freeman
In: 1st International Conference in Drug Design and Discovery, Dubai; 2008.

2008
Computer aided discovery of inhibitors of thymidine phosphorylase and Src

C Stojkoski , V McNally , A Gbaj , G Booker
In: 1st Workshop of Angiokem; Hannover, Germany. 2007.

2007
PAPERS AND PUBLICATIONS OF ZAYED CENTRE

FA Rihan , DH Abdelrahman , F Al-Maskari , F Ibrahim
Plos One 9 e99163 -e99163

2014
Enzyme adsorption by drug aggregates: probing the molecular basis of inhibitor promiscuity using molecular dynamics simulations

M Ghattas , N Atatreh , S Alrawashdeh , R Bryce
EUROPEAN JOURNAL OF CANCER 103 E68 -E69

2018
Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds

SS AlNeyadi , AA Salem , MA Ghattas , N Atatreh
vitro 270 -282

8
2017
The discovery of potential CDK2-Spy1 inhibitors via structure-based drug design

N Atatreh , M Al Sorkhy , S Al Rawashdah , M Ghattas
EUROPEAN JOURNAL OF CANCER 103 E93 -E94

2018
Virtual screening and in vitro evaluation of non-kinase inhibitors of c-Src-SH3 protein-protein interactions

Cvetan Stojkoski , Sally Freeman , Richard Bryce , Phillippa Smith
Molecular Cancer Therapeutics 6

2007
In silico design of new MPS1 inhibitors via a validated structure-based virtualscreening approach

Mohammad Al Sorkhy , Mohammad A. Ghattas , Noor Atatreh
Der Pharma Chemica 8 ( 2) 365 -374

2016
Computer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease

Mohammad A. Ghattas , Bassam R. Ali , Noor Atatreh , Shaima Hasan
Acta Pharmaceutica 71 ( 3) 325 -333

2021
How Do Small Molecule Aggregates Inhibit Enzyme Activity? A Molecular Dynamics Study

Mohammad A. Ghattas , Sara Al Rawashdeh , Noor Atatreh , Richard A. Bryce
Journal of Chemical Information and Modeling 60 ( 8) 3901 -3909

1
2020
Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds.

Noor Atatreh , Amal M Youssef , Mohammad A Ghattas , Mohammad Al Sorkhy
Bioorganic Chemistry 86 393 -400

11
2019
Molecular modelling studies on ɑ7 nicotinic receptor allosteric modulators yields novel filter-based virtual screening protocol.

Sara Al Rawashdah , Amar Hamrouni , Bassem Sadek , Rawad Amer
Journal of Molecular Graphics & Modelling 92 44 -54

2019
Computer-aided discovery of antimicrobial agents as potential enoyl acyl carrier protein reductase inhibitors

Mohammad A Ghattas , Nermin A Eissa , Sanaa K Bardaweel , Abdallah Abu Mellal
Tropical Journal of Pharmaceutical Research 16 ( 2) 397 -405

2
2017
In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand

Noor Atatreh , Cvetan Stojkoski , Phillippa Smith , Grant W. Booker
Bioorganic & Medicinal Chemistry Letters 18 ( 3) 1217 -1222

19
2008
Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity.

Mohammad A. Ghattas , Richard A. Bryce , Sara Al Rawashdah , Noor Atatreh
ChemMedChem 13 ( 6) 500 -506

4
2018
Protein tyrosine phosphatases: Ligand interaction analysis and optimisation of virtual screening

Mohammad A. Ghattas , Noor Atatreh , Elena V. Bichenkova , Richard A. Bryce
Journal of Molecular Graphics and Modelling 52 114 -123

9
2014
Druggability analysis and classification of protein tyrosine phosphatase active sites.

Mohammad Ghattas , Noor Raslan , Asil Sadeq , Mohammad Al Sorkhy
Drug Design Development and Therapy 10 3197 -3209

17
2016