A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

Brian A Kelch Xingchen Liu , Christl Gaubitz , Joshua Pajak
Elife 11 e77483

1
2022
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation.

Paul J. Jardine , Gaurav Arya , Brendan J. Hilbert , Rockney Atz
Proceedings of the National Academy of Sciences of the United States of America 118 ( 17)

2021
A viral genome packaging motor transitions between cyclic and helical symmetry to translocate dsDNA.

Michael Woodson , Joshua Pajak , Bryon P Mahler , Wei Zhao
Science Advances 7 ( 19)

2021
Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor.

Joshua Pajak , Erik Dill , Emilio Reyes-Aldrete , Mark A White
Nucleic Acids Research

2021
Functional Dissection of a Viral DNA Packaging Machine's Walker B Motif.

Damian delToro , David Ortiz , Mariam Ordyan , Joshua Pajak
Journal of Molecular Biology 431 ( 22) 4455 -4474

7
2019
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

Christl Gaubitz , Xingchen Liu , Joshua Pajak , Nicholas P Stone
Elife 11 e74175

12
2022
Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes

Vanessa Simões , Blanche K Cizubu , Lana Harley , Ye Zhou
Cell reports 39 ( 8)

17
2022
Biophysics of DNA packaging

Joshua Pajak , Gaurav Arya , Douglas E Smith
Academic Press 160 -166

6
2021
Molecular dynamics of DNA translocation by FtsK

Joshua Pajak , Gaurav Arya
Nucleic Acids Research 50 ( 15) 8459 -8470

1
2022
Conformational dynamics control assembly of an extremely long bacteriophage tail tube

Emily Agnello , Joshua Pajak , Xingchen Liu , Brian A Kelch
Journal of Biological Chemistry 299 ( 3)

4
2023
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication

Jacob T Landeck , Joshua Pajak , Emily K Norman , Emma L Sedivy
Journal of Biological Chemistry 300 ( 4)

1
2024