Human stem cell research for potential drug-induced cardiac arrhythmias and neuronal side effects: Janssen's strategy

Hua Rong Lu , Ivan Kopljar , Kreir Mohamed , Ard Teisman
Toxicology Letters 280

2017
Voltage-gated sodium channel (Na V ) protein dissection creates a set of functional pore-only proteins

D. Shaya , M. Kreir , R. A. Robbins , S. Wong
Proceedings of the National Academy of Sciences of the United States of America 108 ( 30) 12313 -12318

93
2011
Natural and artificial ion channels for biosensing platforms

L. Steller , M. Kreir , R. Salzer
Analytical and Bioanalytical Chemistry 402 ( 1) 209 -230

55
2012
Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?

M. Kreir , B. Van Deuren , S. Versweyveld , A. De Bondt
Toxicology and Applied Pharmacology 346 45 -57

15
2018
Resistive pulse sensing with biological nanopores

Maurits R.R. de Planque , Niels Fertig , Jiajun Wang , Mohamed Kreir

2014
New applications of automated electrophysiology: heat activation of TRPV1 and action potentials of cardiomyocytes

Sonja Stoelzle , Matthias Beckler , Niels Fertig , Juergen Steindl
The FASEB Journal 24

2010
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System

Katrien Neyrinck , Johanna Van Den Daele , Tim Vervliet , Jonathan De Smedt
Stem Cell Reviews and Reports 1 -19

15
2021
Planar patch clamp: advances in electrophysiology.

Andrea Brüggemann , Cecilia Farre , Claudia Haarmann , Ali Haythornthwaite
Methods of Molecular Biology 491 165 -176

44
2008
Cell-free expression of a functional pore-only sodium channel.

Emil Gustavsson , Jiajun Wang , Mohamed Kreir , Sebastian Peuker
Protein Expression and Purification 111 42 -47

6
2015
Functional characterization of p7 viroporin from hepatitis C virus produced in a cell-free expression system.

Thomas Soranzo , Sandra Cortès , Flora Gilde , Mohamed Kreir
Protein Expression and Purification 118 83 -91

8
2016
Ion Channel Reconstitution on a Pore-Suspending Membrane on Microstructured Glass Chip: Towards Artificial Gap Junction Formation Between Bilayers and Cells

Mohamed Kreir , Christoph Methfessel , Michael Habig , Mathias Winterhalter
Biophysical Journal 98 ( 3) 708a -709a

2010
Modulation of Thermo-TRP Channels by Temperature in Planar Lipid Bilayers

Mohamed Kreir , Matthias Beckler , Alison Obergrussberger , Ilka Rinke
Biophysical Journal 110 ( 3) 283a

2016
The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes.

Oliver Gaßmann , Mohamed Kreir , Cinzia Ambrosi , Jennifer Pranskevich
Journal of Structural Biology 168 ( 1) 168 -176

24
2009
Parallel and Automated Formation of Lipid Bilayers on Microstructured Chips for Ion Channel and Nanopore Recordings

Gerhard Baaken , Mohamed Kreir , Astrid Seifert , Matthias Beckler
Biophysical Journal 104 ( 2)

2013
Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching

Bert Billen , Marijke Brams , Sarah Debaveye , Alina Remeeva
Journal of Biological Chemistry 290 ( 20) 12964 -12974

6
2015
Detecting drug-induced delayed cardiac effects using human stem cell-derived cardiomyocytes

Gabriela T. Carrasqueiro , Mohamed Kreir , Eddy Vlaminckx , Ard Teisman
Journal of Pharmacological and Toxicological Methods 105 106721

2020
In vitro assessments of drug-induced delayed cardiotoxicity using human stem cell-derived cardiomyocytes

Hua Rong Lu , Eddy Vlaminckx , Danny Geysken , Gabriela T. Carrasqueiro
Journal of Pharmacological and Toxicological Methods 105 106851

2020
The translational discrepancy in the assessment of seizure risk for antidepressants and antipsychotics

Mohamed Kreir , Greet Teuns , Hua Rong Lu , David Gallacher
Journal of Pharmacological and Toxicological Methods 105 106772

2020
Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes

Mohamed Kreir , Cecilia Farre , Matthias Beckler , Michael George
Lab on a Chip 8 ( 4) 587 -595

81
2008