Francesc Xavier Ruiz
机构: Associate Professor, Center for Advanced Biotechnology & Medicine, Rutgers University, New Jersey
每年引用次数
引用次数
引用: 2,161
H-指数: 25
I10-指数 : 38
出版物: 56
Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1
F. Xavier Ruiz , Anthony Hoang , Kalyan Das , Eddy Arnold
Journal of Medicinal Chemistry 62 ( 21) 9996 -10002
16
2019
Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling
F. Xavier Ruiz , Sergio Porté , Xavier Parés , Jaume Farrés
Frontiers in Pharmacology 3 58 -58
100
2012
Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels.
F. Xavier Ruiz , Oriol Gallego , Albert Ardèvol , Armando Moro
Chemico-Biological Interactions 178 ( 1) 171 -177
63
2009
Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde
F. Xavier Ruiz , Armando Moro , Oriol Gallego , Albert Ardèvol
Chemico-Biological Interactions 191 ( 1) 199 -205
22
2011
Aldo-keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivity
Sergio Porté , F. Xavier Ruiz , Joan Giménez , Iago Molist
Chemico-Biological Interactions 202 186 -194
27
2013
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.
Dongwei Kang , F. Xavier Ruiz , Da Feng , Alyssa Pilch
Journal of Medicinal Chemistry 63 ( 3) 1298 -1312
10
2020
Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders.
Gabrielle Zeder-Lutz , Laurence Choulier , Marie Besse , Alexandra Cousido-Siah
Analytical Biochemistry 421 ( 2) 417 -427
10
2012
Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily
F. Xavier Ruiz , Sergio Porté , Oriol Gallego , Armando Moro
Biochemical Journal 440 ( 3) 335 -347
29
2011
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.
Oriol Gallego , Olga V. Belyaeva , Sergio Porté , F. Xavier Ruiz
Biochemical Journal 399 ( 1) 101 -109
131
2006
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10
O. Gallego , F. X. Ruiz , A. Ardevol , M. Dominguez
Proceedings of the National Academy of Sciences of the United States of America 104 ( 52) 20764 -20769
138
2007
Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance.
Francesc Xavier RUIZ , Eddy Arnold
Current Opinion in Structural Biology 61 113 -123
32
2020
Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: effects on CK2α activity
Franc Llorens , Nerea Roher , Francesc A Miró , Stefania Sarno
Biochemical Journal 375 ( 3) 623 -631
46
2003
Generation of biological association networks: A novel strategy to detect new targets in cancer therapy
Elisabet Selga i Coma , Ma Cristina de Almagro García , Carlota Oleaga Sancho , Núria Mencía Trinchant
Recent Advances in Pharmaceutical Sciences, 2011, Chapter 1, p. 1-33. Editor: Diego Muñoz-Torrero
2011
Kinetic Analysis of SDRs, ADHs and AKRs toward Free and CRBPI
Olga V Belyaeva Oriol Gallego , Sergio Porté , F Xavier Ruiz , Anton V Stetsenko
Enzymology and Molecular Biology of Carbonyl Metabolism 13 144 -144
2007
New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.
Firas Fadel , Yuguang Zhao , Raul Cachau , Alexandra Cousido-Siah
Acta Crystallographica Section D-biological Crystallography 71 ( 7) 1455 -1470
12
2015
Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design.
Alexandra Cousido-Siah , Francesc X. Ruiz , André Mitschler , Sergio Porté
Acta Crystallographica Section D-biological Crystallography 70 ( 3) 889 -903
22
2014
Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase
Joan Giménez-Dejoz , Michal H. Kolář , Francesc X. Ruiz , Isidro Crespo
PLOS ONE 10 ( 7) e0134506
12
2015
Crystal packing modifies ligand binding affinity: The case of aldose reductase.
Alexandra Cousido-Siah , Tatiana Petrova , Isabelle Hazemann , André Mitschler
Proteins 80 ( 11) 2552 -2561
11
2012
Structural Determinants of the Selectivity of 3‐Benzyluracil‐1‐acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10
Francesc X. Ruiz , Alexandra Cousido-Siah , Sergio Porté , Marta Domínguez
ChemMedChem 10 ( 12) 1989 -2003
6
2015
Cover Picture: Structural Determinants of the Selectivity of 3‐Benzyluracil‐1‐acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10 (ChemMedChem 12/2015)
Francesc X. Ruiz , Alexandra Cousido-Siah , Sergio Porté , Marta Domínguez
ChemMedChem 10 ( 12) 1941 -1941
2015