moléculas com núcleo híbrido, composição farmacêutica, processo de síntese e seus usos

Laurent Emmanuel Dardenne , Eduardo Luis Konrath , Marco Antonio Ceschi , Isabella Alvim Guedes

2015
molécula híbrida contendo núcleos imidazólicos, arílicos e benzílicos, composição farmacêutica, processo de síntese e seus usos

Marco Antonio Ceschi , Viktor Saraiva Câmara , Ana Júlia Soares , Cristiane Martins Cardoso De Salles

2017
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives.

João Paulo Bizarro Lopes , Luana Silva , Gabriela da Costa Franarin , Marco Antonio Ceschi
Bioorganic & Medicinal Chemistry 26 ( 20) 5566 -5577

9
2018
A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA.

Mariana Severo Ramundo , Cristiana Ossaille Beltrame , Ana Maria Nunes Botelho , Leonardo Rocchetto Coelho
International Journal of Medical Microbiology 306 ( 6) 367 -380

7
2016
Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases

Cindy Juliet Cristancho Ortiz , Caio Miranda Damasio , Letizia Pruccoli , Nathália Fonseca Nadur
Neurochemical Research 45 ( 12) 3003 -3020

2020
Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.

João Paulo Bizarro Lopes , Luana Silva , Marco Antonio Ceschi , Diogo Seibert Lüdtke
MedChemComm 10 ( 12) 2089 -2101

2
2019
Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.

Marco Antonio Ceschi , Jessie Sobieski da Costa , João Paulo Bizarro Lopes , Viktor Saraiva Câmara
European Journal of Medicinal Chemistry 121 758 -772

27
2016
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.

Flávia Pereira Dias Viegas , Matheus de Freitas Silva , Miguel Divino da Rocha , Maísa Rosa Castelli
European Journal of Medicinal Chemistry 147 48 -65

42
2018
Anti-restriction gene homologs are highly represented in Methicillin-resistant and multidrug-resistant Staphylococcus aureus ST239 and ST398: implications for resistance gene acquisitions

Deborah Nascimento Santos Silva , Cristiana Ossaille Beltrame , Ana Maria Nunes Botelho , Caroline Lopes Martini
Antibiotics 11 ( 9) 1217

1
2022
Analysis of a novel class A β-lactamase OKP-B-6 of Klebsiella quasipneumoniae: structural characterisation and interaction with commercially available drugs

Reinaldo Bellini , Isabella Alvim Guedes , Luciane Prioli Ciapina , Ana Tereza Ribeiro de Vasconcelos
Memórias do Instituto Oswaldo Cruz 117 e220102 -e220102

2022
DockThor-VS: A Free Docking Server For Protein-Ligand Virtual Screening using the Supercomputer SDumont

Isabella Alvim Guedes , Eduardo Krempser , André Barreto , Camila Magalhães
Galoá

1
2019
2017
Moléculas híbridas contendo núcleos tacrina e esquárico, composição farmacêutica, processo de síntese e seus usos

Marco Antonio Ceschi , Renan Michael Pilotti , João Paulo Bizarro Lopes , Joao Batista Teixeira da Rocha

2021
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.

Matheus de Freitas Silva , Ellen Tardelli Lima , Letizia Pruccoli , Newton G Castro
Molecules 25 ( 14) 3165

2020
Design, synthesis, and biological evaluation of new thalidomide–donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation

Cindy Juliet Cristancho Ortiz , Matheus de Freitas Silva , Letizia Pruccoli , Nathália Fonseca Nadur
RSC Medicinal Chemistry 13 ( 5) 568 -584

5
2022
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease

Sarah Macedo Vaz , Matheus de Freitas Silva , Graziella dos Reis Rosa Franco , Marcos Jorge R Guimarães
Bioorganic & Medicinal Chemistry 71 116952 -116952

6
2022
A computational approach to evaluate critical Spike protein mutations in non-synonymous variants of SARS-CoV-2

Leon SC Costa , Isabella Alvim Guedes , Haron Calegari Fanticelli , Marisa F Nicolás
Galoá

2022
Carbapenem resistance in non-carbapenemase-producing Pseudomonas aeruginosa strains: the role importance of OprD and AmpC

Keila de Cássia Ferreira de Almeida , Felipe Lopes Teixeira , Diana Legal Ferreira Paiva , Isabelle Ruiz Martins
Research, Society and Development 11 ( 13) e287111335164 -e287111335164

2
2022