Miguel Moutinho
机构: Stark Neurosciences Research Institute
每年引用次数
引用次数
引用: 1,073
H-指数: 18
I10-指数 : 23
出版物: 41
Control of neuronal signalling pathways by CYP46A1, an enzime involved in brain cholesterol homeostasis
Miguel Alves da Silva de Moutinho
2016
INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.
Adrian L. Oblak , Kwangsik Nho , Brad T. Casali , Gary E. Landreth
Neurobiology of Disease 153 105303
2
2021
Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond
Miguel Moutinho , Maria João Nunes , Elsa Rodrigues
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861 ( 12) 1911 -1920
21
2016
Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter
Inês Milagre , Maria João Nunes , Margarida Castro-Caldas , Miguel Moutinho
Journal of Neurochemistry 120 ( 2) 220 -229
13
2012
Characterization of new G protein-coupled adenine receptors in mouse and hamster
Dominik Thimm , Melanie Knospe , Aliaa Abdelrahman , Miguel Moutinho
Purinergic Signalling 9 ( 3) 415 -426
26
2013
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease
Paul J. Cheng-Hathaway , Erin G. Reed-Geaghan , Taylor R. Jay , Brad T. Casali
Molecular Neurodegeneration 13 ( 1) 29 -29
146
2018
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Vaishnavi S. Jadhav , Peter B. C. Lin , Taylor Pennington , Gonzalo Viana Di Prisco
Molecular Neurodegeneration 15 ( 1) 62 -62
21
2020
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
Miguel Moutinho , Maria João Nunes , Jorge C. Correia , Maria João Gama
Scientific Reports 6 ( 1) 30928
13
2016
Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.
Maria João Nunes , Miguel Moutinho , Inês Milagre , Maria João Gama
Journal of Lipid Research 53 ( 9) 1910 -1919
10
2012
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.
Miguel Moutinho , Maria João Nunes , Anita Q. Gomes , Maria João Gama
Molecular Neurobiology 51 ( 3) 1489 -1503
14
2015
Therapeutic potential of niacin in Alzheimer's disease: Nonhuman/Target identification and validation studies: Other
Miguel Moutinho , Andy P. Tsai , Shweta S Puntambekar , Jheel Patel
Alzheimers & Dementia 16
2020
Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux
Maria João Nunes , Miguel Moutinho , Maria João Gama , Cecília M. P. Rodrigues
PLoS ONE 8 ( 1) e53394
22
2013
The mevalonate pathway in neurons: It's not just about cholesterol.
Miguel Moutinho , Maria João Nunes , Elsa Rodrigues
Experimental Cell Research 360 ( 1) 55 -60
35
2017
PLCG2 as a Risk Factor for Alzheimer's Disease
Andy P. Tsai , Chuanpeng Dong , Christoph Preuss , Miguel Moutinho
bioRxiv
1
2020
Therapeutic potential of nuclear receptor agonists in Alzheimer's disease
Miguel Moutinho , Gary E. Landreth
Journal of Lipid Research 58 ( 10) 1937 -1949
34
2017
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation.
Miguel Moutinho , Juan F. Codocedo , Shweta S. Puntambekar , Gary E. Landreth
Annual Review of Pharmacology and Toxicology 59 ( 1) 237 -261
9
2019
Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining.
Inês Palmela , Hiroyuki Sasaki , Filipa L. Cardoso , Miguel Moutinho
Frontiers in Cellular Neuroscience 6 22 -22
35
2012
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease
Miguel Moutinho , Shweta S Puntambekar , Andy P Tsai , Israel Coronel
Science translational medicine 14 ( 637) eabl7634
12
2022
CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
Shweta S Puntambekar , Miguel Moutinho , Peter Bor-Chian Lin , Vaishnavi Jadhav
Molecular neurodegeneration 17 ( 1) 1 -21
10
2022
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation
Miguel Moutinho , Israel Coronel , Andy P Tsai , Gonzalo Viana Di Prisco
Genome Medicine 15 ( 1) 1 -16
2023