Osmotic Regulation Is Required for Cancer Cell Survival under Solid Stress

Daniel J. McGrail , Kathleen M. McAndrews , Chandler P. Brandenburg , Nithin Ravikumar
Biophysical Journal 109 ( 7) 1334 -1337

45
2015
Mechanical and architectural properties of cross-linked gelatin scaffolds direct the differentiation of mesenchymal stem cells

Kathleen M McAndrews , Michelle R. Dawson , Daniel James McGrail , Min Jeong Kim
Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting

2014
Utilizing multiple particle tracking microrheology and traction force microscopy to monitor mechanical progression of differentiating mesenchymal stem cells

N. Quach , Kathleen M McAndrews , M. R. Dawson , Daniel James McGrail
Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future 853 -854

2013
Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer.

Fernanda G Kugeratski , Kathleen M McAndrews , Raghu Kalluri , Raghu Kalluri
Endocrinology 162 ( 3)

2021
Spatially coordinated changes in intracellular rheology and extracellular force exertion during mesenchymal stem cell differentiation

Kathleen M McAndrews , Daniel J McGrail , Nhat D Quach , Michelle R Dawson
Physical Biology 11 ( 5) 056004 -056004

8
2014
A map of human breast cancer: new players in stromal-immune crosstalk.

Kathleen M McAndrews , Raghu Kalluri
The EMBO Journal 39 ( 19)

2020
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer

Kathleen M McAndrews , Fei Xiao , Antonios Chronopoulos , Valerie S LeBleu
Life science alliance 4 ( 9)

32
2021
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker

Fernanda G Kugeratski , Kelly Hodge , Sergio Lilla , Kathleen M McAndrews
Nature Cell Biology 23 ( 6) 631 -641

128
2021
Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta

Yang Chen , Sujuan Yang , Sara Lovisa , Catherine G Ambrose
Nature communications 12 ( 1) 7199

9
2021
Clinical and therapeutic relevance of cancer-associated fibroblasts

Yang Chen , Kathleen M McAndrews , Raghu Kalluri
Nature reviews Clinical oncology 18 ( 12) 792 -804

169
2021
Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer

Kathleen M McAndrews , Yang Chen , J Kebbeh Darpolor , Xiaofeng Zheng
Cancer discovery 12 ( 6) 1580 -1597

33
2022
KLF5 governs sphingolipid metabolism and barrier function of the skin

Ying Lyu , Yinglu Guan , Lisa Deliu , Ericka Humphrey
Genes \& Development 36 ( 13-14) 822 -842

2022
2024
Abstract PO-059: Epithelial/mesenchymal identity dictates pancreatic cancer cell metastasis

Julienne L Carstens , Sujuan Yang , Pedro Correa de Sampaio , Xiaofeng Zheng
Cancer Research 81 ( 22 Supplement) PO -PO

2021
Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

Krishnan K Mahadevan , Valerie S LeBleu , Elena V Ramirez , Yang Chen
Developmental cell 58 ( 17) 1562 -1577. e8

8
2023
Abstract B082: Extinction of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8+ T cells

Valerie S LeBleu , Krishnan K Mahadevan , Elena V Ramirez , Yang Chen
Cancer Research 84 ( 2_Supplement) B082 -B082

2024
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2

Lamiaa El-Shennawy , Andrew D Hoffmann , Nurmaa Khund Dashzeveg , Kathleen M McAndrews
Nature communications 13 ( 1) 405 -405

119
2022
KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

Krishnan K Mahadevan , Kathleen M McAndrews , Valerie S LeBleu , Sujuan Yang
Cancer Cell 41 ( 9) 1606 -1620. e8

36
2023
Phase I study of mesenchymal stem cell (MSC)-derived exosomes with KRASG12D siRNA in patients with metastatic pancreatic cancer harboring a KRASG12D mutation.

Rishi Surana , Valerie S LeBleu , J Jack Lee , Brandon George Smaglo
Journal of Clinical Oncology 40 ( 4_suppl) TPS633 -TPS633

15
2022