Hezekiel Khumalo
机构: School of Laboratory and Medical Sciences, Department of medical Biochemistry, University of KwaZulu
每年引用次数
引用次数
引用: 1,130
H-指数: 18
I10-指数 : 33
出版物: 95
Per-Residue Energy Footprints-Based Pharmacophore Modeling as an Enhanced In Silico Approach in Drug Discovery: A Case Study on the Identification of Novel β-Secretase1 (BACE1) Inhibitors as Anti-Alzheimer Agents
H. M. Kumalo , Mahmoud E. Soliman
Cellular and Molecular Bioengineering 9 ( 1) 175 -189
25
2016
A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility
H. M. Kumalo , Mahmoud E. Soliman
Journal of Receptors and Signal Transduction 36 ( 5) 505 -514
13
2016
In Vitro Antibacterial Activity of Teixobactin Derivatives on Clinically Relevant Bacterial Isolates.
E. J. Ramchuran , A. Somboro , S. A. Monaim , D. G. Amoako
Frontiers in Microbiology 9 1535
14
2018
Understanding the Binding Mechanism of Antagonist (AZD3293) Against BACE-1: Molecular Insights into Alzheimer’s Drug Discovery
Sphelele Sosibo , Daniel Gyamfi Amoako , Anou Moise Somboro , Darren Delai Sun
Letters in Drug Design & Discovery 17 ( 7) 850 -857
2020
Mechanism of Inhibition of Hsp90 Dimerization by Gyrase B Inhibitor Coumermycin A1 (C–A1) Revealed by Molecular Dynamics Simulations and Thermodynamic Calculations
Favourite N. Cele , Hezekiel Kumalo , Mahmoud E. S. Soliman
Cell Biochemistry and Biophysics 74 ( 3) 353 -363
4
2016
Theory and Applications of Covalent Docking in Drug Discovery: Merits and Pitfalls
Hezekiel Kumalo , Soumendranath Bhakat , Mahmoud Soliman
Molecules 20 ( 2) 1984 -2000
77
2015
Susceptibility of Anopheles Mosquito to Agricultural Insecticides in the Adansi North District, Ghana
Nicholas Egyir , Bernard Lawson , Kwame Desewu , Rosemary Ampofo-Bekoe
Journal of Pure and Applied Microbiology 13 ( 2) 677 -688
2019
“Mango in all her majesty”—the potential of mangiferin and its analogues in the inhibition of Eimeria tenella hexokinase—a computational approach
Kehinde F Paul-Odeniran , Paul O Odeniran , Isaiah O Ademola , Hezekiel Kumalo
Journal of Biomolecular Structure and Dynamics 41 ( 11) 5291 -5304
2023
In vitro potentiation of carbapenems with tannic acid against carbapenemase‐producing enterobacteriaceae: exploring natural products as potential carbapenemase inhibitors
A.M. Somboro , J. Osei Sekyere , D.G. Amoako , H.M. Kumalo
Journal of Applied Microbiology 126 ( 2) 452 -467
7
2019
Toxicogenicity and mechanistic pathways of aflatoxin B1 induced renal injury.
Anou M Somboro , Daniel G Amoako , Rene B Khan , Hezekiel M Khumalo
Environmental Toxicology
4
2021
Molecular mechanisms underlying Warburgia salutaris effects on oxidative stress and apoptotic parameters in Human Hepatoma Cells
Lebogang N Maruma , Anou M Somboro , Daniel G Amoako , Hezekiel M Khumalo
bioRxiv 2022.03. 05.483129 -2022.03. 05.483129
2022
The toxicogenic effect of Terminalia phanerophlebia Engl. & Diels leaf extract on oxidative stress parameters in an in vitro Hek293 model
Marcilyn R Nyahada , Daniel G Amoako , Anou M Somboro , Isaiah Arhin
Journal of Pharmacy & Pharmacognosy Research 9 ( 3) 261 -271
2021
Mechanistic Insights into Oxidative Stress and Apoptosis Mediated by Tannic Acid in Human Liver Hepatocellular Carcinoma Cells
Priscilla Mhlanga , Pearl O Perumal , Anou M Somboro , Daniel G Amoako
International Journal of Molecular Sciences 20 ( 24) 6145
5
2019
Cytoproliferative and Anti-Oxidant Effects Induced by Tannic Acid in Human Embryonic Kidney (Hek-293) Cells
Pearl O Perumal , Priscilla Mhlanga , Anou M Somboro , Daniel G Amoako
Biomolecules 9 ( 12) 767
5
2019
Di-2-picolylamine triggers caspase-independent apoptosis by inducing oxidative stress in human liver hepatocellular carcinoma cells.
Thobeka Madide , Anou M Somboro , Daniel G Amoako , Hezekiel M Khumalo
Biotechnology and Applied Biochemistry 68 ( 2) 257 -266
2
2021
A molecular dynamics perspective into estrogen receptor inhibition by selective flavonoids as alternative therapeutic options
Angela Sinyani , Kehinde Idowu , Letitia Shunmugam , Hezekiel Mathambo Kumalo
Journal of Biomolecular Structure and Dynamics 41 ( 9) 4093 -4105
10
2023
Adsorption and Potential Covalent Immobilisation of Peptides Onto Mica Substrates
Hezekiel Mathambo Kumalo
University of KwaZulu-Natal, Durban
2013
Mechanistic Insights into Targeting SARS-CoV-2 Papain-Like Protease in the Evolution and Management of COVID-19: A Comprehensive Review
NONJABULO N MAGWAZA , AGANZE MUSHEBENGE , SAMUEL CHIMA UGBAJA , NONKULULEKO AVRIL MBATHA
Preprints
2023
Influenza Viruses: Harnessing the Crucial Role of the M2 Ion-Channel and Neuraminidase toward Inhibitor Design
Hezekiel M Kumalo , Anou M Somboro , Monsurat M Lawal , Daniel G Amoako
Molecules 26 ( 4) 880
2021
In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis.
Katharigatta N Venugopala , Christophe Tratrat , Melendhran Pillay , Sandeep Chandrashekharappa
Drug Design Development and Therapy 14 1027 -1039
11
2020