William Greenlee
机构: Medchem Discovery Consulting
每年引用次数
引用次数
引用: 14,192
H-指数: 56
I10-指数 : 277
出版物: 579
Editorial overview. The chemistry of drug design and lead optimization.
Desai M , Greenlee Wj
Current Opinion in Drug Discovery & Development 2 ( 4) 264
1999
The chemistry of drug design and lead optimization. Editorial overview.
Desai Mc , Greenlee Wj
Current Opinion in Drug Discovery & Development 1 ( 1) 352
1998
Acute hypotensive responses to peptide inhibitors of renin in conscious monkeys: an effect on blood pressure independent of plasma renin inhibition.
Linda W. Schaffer , Terry W. Schorn , Raymond J. Winquist , John F. Strouse
Journal of Hypertension 8 ( 3) 251 -259
12
1990
An efficient synthesis of γ-amino-β-ketoalkylphosphonates from α-amino acids
P.K Chakravarty , P Combs , A Roth , W.J Greenlee
Tetrahedron Letters 28 ( 6) 611 -612
19
1987
In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996
S KIVLIGHN , G ZINGARO , R GABEL , T BROTEN
American Journal of Hypertension 8 ( 1) 58 -66
17
1995
IN-VIVO PHARMACOLOGY AND ANTIHYPERTENSIVE ACTIVITY OF L-159,282 (MK-996) A NONPEPTIDE ANGIOTENSIN-II (A-II) RECEPTOR ANTAGONIST
PKS Siegl , RA Gabel , GJ Zingaro , T Schorn
FASEB JOURNAL 8 ( 5) A881 -A881
3
1994
USE OF ENZYME CRYSTAL-STRUCTURES AND COMPUTER-GRAPHICS FOR INHIBITOR DESIGN THERMOLYSIN AS A MODEL FOR ANGIOTENSIN CONVERTING ENZYME
D HANGAUER , D ONDEYKA , H BULL , N THORNBERRY
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 190 ( SEP) 50 -MEI
1985
CHEMIE GESPANNTER BINDUNGEN 36. MITT. PHOTOLYSE VON SUBSTITUIERTEN 2,3-DIAZA-BICYCLO(3,1,0)HEXEN-(2)-DERIVATEN, EINFACHER WEG ZU BICYCLO(1,1,0)BUTANEN
PAUL G. GASSMAN , WILLIAM J. GREENLEE
ChemInform 4 ( 16)
1973
Potent imidazo [4, 5-b]-pyridine angiotensin II antagonists which exhibit balanced affinity to the AT1 and AT2 receptor subtypes
NB Mantlo , D Kim , D Ondeyka , RSL Chang
Bioorg Med Chem Lett 4 17 -22
5
1994
Backup programs in drug discovery.
Manoj Desai , William J Greenlee
Current Opinion in Drug Discovery & Development 9 ( 4) 412
1
2006
The role of medicinal chemists in drug discovery.
Manoj C Desai , William J Greenlee
Current Opinion in Drug Discovery & Development 8 ( 4) 419
2005
Editorial overview: Transporter proteins in drug disposition and uptake.
Manoj C Desai , William J Greenlee
Current Opinion in Drug Discovery & Development 7 ( 4) 395 -395
2004
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.
John W Clader , William Billard , Herbert Binch , Lian-Yong Chen
Bioorganic & Medicinal Chemistry 12 ( 2) 319 -326
14
2004
Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors
Yuguang Wang , Samuel Chackalamannil , Zhiyong Hu , Craig D Boyle
Bioorganic & Medicinal Chemistry Letters 12 ( 21) 3149 -3152
28
2002
Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist
David L Williams , Kathryn L Murphy , Nancy A Nolan , Julie A O'Brien
Life Sciences 58 ( 14) 1149 -1157
9
1996
SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction
Dmitri A Pissarnitski , Theodros Asberom , Craig D Boyle , Samuel Chackalamannil
Bioorganic & Medicinal Chemistry Letters 14 ( 5) 1291 -1294
19
2004
(3-Amino-2-oxoalkyl) phosphonic acids and their analogs as novel inhibitors of D-alanine: D-alanine ligase
Prasun K Chakravarty , William J Greenlee , William H Parsons , Arthur A Patchett
Journal of medicinal chemistry 32 ( 8) 1886 -1890
116
1989
Identification of a selective SCoR2 inhibitor that protects against acute kidney injury
Hua-Lin Zhou , Alfred Hausladen , Puneet Anand , Malligarjunan Rajavel
Journal of medicinal chemistry 66 ( 8) 5657 -5668
2023
Design and synthesis of novel b-secretase (BACE) inhibitors
Robert D Mazzola Jr , Suresh Babu , John Caldwell , Xia Chen
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240
2010
Modeling novel planar BACE1 inhibitors: Trying to hit a moving target
Johannes Voigt , John Caldwell , Samuel Chackalamannil , Xia Che
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 238
2009