Andre Rosowsky
机构: Associate Professor (retired)
每年引用次数
引用次数
引用: 9,921
H-指数: 54
I10-指数 : 198
出版物: 400
Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
J. E. Wright , A. Rosowsky , Guan Chen
Molecular Pharmacology 48 ( 4) 758 -765
13
1995
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
J. Galivan , B. M. O'Connor , H. Bader , A. Rosowsky
Cancer Research 52 ( 8) 2148 -2155
21
1992
Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture
E. Frei , A. Rosowsky , J. E. Wright , C. A. Cucchi
Proceedings of the National Academy of Sciences of the United States of America 81 ( 9) 2873 -2877
59
1984
Alkylating agent resistance: in vitro studies with human cell lines
E. Frei , C. A. Cucchi , A. Rosowsky , R. Tantravahi
Proceedings of the National Academy of Sciences of the United States of America 82 ( 7) 2158 -2162
126
1985
An analytical method to compute an approximate value of the site percolation threshold Pc
A. Rosowsky
European Physical Journal B 15 ( 1) 77 -86
11
2000
Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
A. Rosowsky , J. B. Hynes , S. F. Queener
Antimicrobial Agents and Chemotherapy 39 ( 1) 79 -86
34
1995
Methotrexate-Carboxypeptidase G1: A Selective Approach to CNS Neoplasia
H. T. Abelson , W. Ensminger , A. Rosowsky , J. Uren
Palgrave Macmillan, London 390 -396
1
1979
High rotational barriers about CN bonds in aryl substituted heterocyclic compounds lacking bulky ortho substituents
L.D. Colebrook , H.G. Giles , A. Rosowsky
Tetrahedron Letters 13 ( 51) 5239 -5240
4
1972
2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 3. Synthesis of 5,6-disubstituted derivatives and related tetracyclic analogs.
A. Rosowsky , K. K. N. Chen , M. Lin
Journal of Medicinal Chemistry 16 ( 3) 191 -194
66
1973
Pteridines. 2. New 6,7-Disubstituted Pteridines as Potential Antimalarial and Antitumor Agents?,'
A. Rosowsky , M. Chaykovsky , M. Lin , E. J. Modest
Journal of Medicinal Chemistry 16 ( 8) 869 -875
7
1973
Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function
N. Schormann , O. Senkovich , K. Walker , D.L. Wright
Proteins: Structure, Function, and Bioinformatics 73 ( 4) 889 -901
32
2008
Kinetics of Reduced Folate Carrier-and Membrane-Associated Folate Receptor-Mediated Transport of Antifolates
R. Mauritz , G. J. Peters , G. A. M. Kathmann , A. Rosowsky
Chemistry and Biology of Pteridines and Folates 649 -653
1
2002
Methotrexate di-n-butyl ester effects on thymidine metabolism.
G.Peter Beardsley , A. Rosowsky , R.P. McCaffrey , H.T. Abelson
Biochemical Pharmacology 28 ( 20) 3069 -3074
6
1979
Synthesis and in vitro antiviral activity of long-chain 5′-O-alkoxycarbonylphosphinyl)-3′-azido-3′-deoxythymidines against drug-sensitive and AZT- or PFA-resistant human immunodeficiency virus type-1 (HIV-1)
A. Rosowsky , H. Fu , N. Pai , J.W. Mellors
Antiviral Research 34 ( 2)
1
1997
The Chemistry of Fumagillin1
D. S. Tarbell , R. M. Carman , D. D. Chapman , S. E. Cremer
Journal of the American Chemical Society 83 ( 14) 3096 -3113
53
1961
Lipophilic 5'-alkyl phosphate esters of 1-.beta.-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugs
A. Rosowsky , S. H. Kim , J. Ross , M. M. Wick
Journal of Medicinal Chemistry 25 ( 2) 171 -178
41
1982
Synthesis and in vivo antitumor activity of potential 5-fluorouracil prodrugs.
A. Rosowsky , S. H. Kim , D. Trites , M. Wick
Journal of Medicinal Chemistry 25 ( 9) 1034 -1040
16
1982
Methotrexate analogs. 19. Enhancement of the antitumor effect of methotrexate and 3',5'-dichloromethotrexate by the use of lipid-soluble diesters
A. Rosowsky , C. S. Yu
Journal of Medicinal Chemistry 26 ( 10) 1448 -1452
12
1983
Assay for Mitolactol and Its Bifunctional Alkylating Metabolites in Plasma
W.D. Henner , E.A. Furlong , S.L. Kelley , A. Rosowsky
Journal of Pharmaceutical Sciences 74 ( 9) 983 -986
5
1985
Analysis of 4-hydroxycyclophosphamide in human blood.
J.E. Wright , O. Tretyakov , L.J. Ayash , A. Elias
Analytical Biochemistry 224 ( 1) 154 -158
20
1995