Raphaelle Lesage
机构: Scientist - Systems Pharmacology, ESQlabs GmbH
每年引用次数
引用次数
引用: 361
H-指数: 8
I10-指数 : 8
出版物: 32
STUDY OF OSTEOARTHRITIS DEVELOPMENT AND PREDICTION OF POTENTIAL INTERVENTION TARGETS BY AN IN SILICO APPROACH
R Narcisi , T Welting , L Geris , G J V M Van Osch
Orthopaedic Proceedings
2021
SOC-VI-08 Physiological maps: a benchmark tool for adverse outcome pathways and a cornerstone for the development of disease ontologies
Bernard Staumont , Luiz Carlos Maia Ladeira , Alessio Gamba , R Lesage
Toxicology Letters 368
2022
P04-06 New approaches for evaluating kidney toxicity using physiological maps
Alessio Gamba , Luiz Carlos Maia Ladeira , R Lesage , DA Barnes
Toxicology Letters
2022
Designing physiological maps as a tool to study liver toxicology
Luiz Carlos Maia Ladeira , Alessio Gamba , Raphaëlle Lesage , Anouk Verhoeven
21st International Congress ESTIV
2022
Developing a physiological map as a framework to study chemical-induced liver steatosis
Luiz Carlos Maia Ladeira , Alessio Gamba , Raphaëlle Lesage , Anouk Verhoeven
VPH2022 Virtual Physiological Human Conference
2022
First steps for creating an ontology for cognitive function defects for regulatory application
Eliska Kuchovska , Alessio Gamba , Luiz Carlos Maia Ladeira , Bernard Staumont
21st International Congress ESTIV
2022
From Physiological Map to Ontology Unravelling Kidney Toxicity From Physiological Map to Ontology Unravelling Kidney Toxicity
Alessio Gamba , Luiz Carlos Maia Ladeira , Raphaëlle Lesage , Daniël Roodzant
VPH2022 Virtual Physiological Human Conference
2022
Computational modelling of neural tube closure defects
Job Berkhout , Aldert Piersma , Juliette Legler , Alessio Gamba
21st International Congress ESTIV
2022
Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution
Frederik Mølgaard Nielsen , Simone Elkjær Riis , Jens Isak Andersen , Raphaëlle Lesage
Stem Cell Research & Therapy 7 ( 1) 177
13
2016
Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects
Wai Long Tam , Luís Freitas Mendes , Xike Chen , Raphaëlle Lesage
Stem Cell Research \& Therapy 12 ( 1) 1 -16
16
2021
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility
Flora T Musuamba , Ine Skottheim Rusten , Raphaëlle Lesage , Giulia Russo
CPT: Pharmacometrics & Systems Pharmacology 10 ( 8) 804 -825
65
2021
Physiological maps and chemical-induced disease ontologies: tools to support NAMs development for next-generation risk assessment
Luiz Carlos Maia Ladeira , Alessio Gamba , Raphaëlle Lesage , Eliska Kuchovska
ASPIS Open Symposium
2022
P11-09 Physiology-based framework to study chemical-induced cholestasis
Luiz Carlos Maia Ladeira , Alessio Gamba , Raphaëlle Lesage , J van Ertvelde
Toxicology Letters 368
2022
Verifying and validating quantitative systems pharmacology and in silico models in drug development: current needs, gaps, and challenges
Flora T Musuamba , Roberta Bursi , Efthymios Manolis , Kristin Karlsson
CPT: Pharmacometrics & Systems Pharmacology 9 ( 4) 195 -195
20
2020
Mapping the use of computational modelling and simulation in clinics: A survey
Raphaëlle Lesage , Michiel Van Oudheusden , Silvia Schievano , Ine Van Hoyweghen
Frontiers in medical technology 5 1125524 -1125524
7
2023
An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis
Raphaëlle Lesage , Mauricio N Ferrao Blanco , Roberto Narcisi , Tim Welting
Bmc Biology 20 ( 1) 253 -253
3
2022
An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis
Raphaëlle Lesage , Mauricio N Ferrao Blanco , Roberto Narcisi , Tim Welting
bioRxiv 2021.09. 27.461207 -2021.09. 27.461207
2
2021
Model Credibility
Eulalie Courcelles , Marc Horner , Payman Afshari , Alexander Kulesza
Toward Good Simulation Practice: Best Practices for the Use of Computational Modelling and Simulation in the Regulatory Process of Biomedical Products 43 -66
2024
Physiological map to study kidney toxicity in the ONTOX project
Alessio Gamba , Luiz Carlos Maia Ladeira , Raphaëlle Lesage , Daniël Roodzant
21st International Congress ESTIV
2022