Concise synthesis of CC-1065/duocarmycin pharmacophore using the intramolecular Heck reaction
作者： Takao Sakamoto , Yoshinori Kondo , Masanobu Uchiyama , Hiroshi Yamanaka
DOI: 10.1039/P19930001941
关键词: Duocarmycin 、 Chemistry 、 Intramolecular reaction 、 Pharmacophore 、 Intramolecular force 、 Heck reaction 、 Bicyclic molecule 、 Stereochemistry
摘要: 3-Methyleneindoline derivatives were synthesized by intramolecular Heck reaction of N-allyl-2-iodoaniline in the presence Ag2Co3. This method was successfully applied to synthesis CC-1065/duocarmycin pharmacophore.
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