Bispecific antibody for cancer immunotherapy

作者: Marco L. Davila

DOI:

关键词: CellAntigenImmune systemBinding domainViral vectorCell biologyHeparinChemistryCancer immunotherapyChimeric antigen receptor

摘要: Disclosed are compositions and methods for gene transfer in immune effector cells, e.g. to create chimeric antigen receptors (CARs). In particular, polypeptides disclosed that comprising an antigen-binding region a heparin binding domain, wherein the is capable of specifically cell located on cell, domain viral vector.

参考文章(6)
Laura De LaPorte, Federico Tortelli, Jeffrey J. Rice, Mikael Martino, Jeffrey A. Hubbell, Extracellular matrix heparin-binding domains ,(2013)
Takashi Uemori, Kiyozo Asada, Ikunoshin Kato, Kimikazu Hashino, Nobuto Koyama, Takashi Ueno, Method for gene transfer into target cells with retrovirus ,(2005)
Sally J. Denardo, Gerald L. Denardo, Rodney L. Balhorn, Selective high-affinity polydentate ligands and methods of making such ,(2009)
Mitsuko Ideno, Tatsuji Enoki, Meiko Jin, 美津子 出野, 芽衣子 神, 榎 竜嗣, Process for production of cytokine-induced killer cells ,(2010)