BAP1 Loss Predicts Therapeutic Vulnerability in Malignant Peritoneal Mesothelioma
作者： Stanislav Volik , Antonio Hurtado-Coll , Anne Haegert , Ladan Fazli , Robert Shukin
DOI: 10.1101/243477
关键词: Medicine 、 Immune checkpoint 、 Cancer research 、 DNA Repair Pathway 、 Malignant Peritoneal Mesothelioma 、 Chemotherapy 、 BAP1 、 Precision medicine 、 Cancer 、 Chromatin remodeling
摘要: Malignant Peritoneal Mesothelioma (PeM) is a rare but frequently fatal cancer that originates from the peritoneal lining of abdomen. Standard treatment PeM limited to cytoreductive surgery and/or chemotherapy, and no effective targeted therapies for yet exist. In search novel therapeutic target candidates in PeM, we performed comprehensive integrative multi-omics analysis 19 treatment-naive tumors. The identified tumors with BAP1 loss form distinct molecular subtype characterized by expression patterns genes involved chromatin remodeling, DNA repair pathway, immune checkpoint receptor activation. This could potentially benefit checkpoint, PARP, or HDAC inhibition therapies. Our findings uncover as trackable prognostic predictive biomarker, refine disease classification. integrated characterization provides foundation developing precision medicine.
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