Aminopyrazole derivatives as gsk-3 inhibitors

作者: Daniel Wei-Shung Kung , John William Benbow

DOI:

关键词: GSK-3ChemistryPharmacologyProdrug

摘要: The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, pharmaceutically acceptable salts compounds, stereoisomers, prodrugs, wherein R1, R2, R3 are as defined herein; pharmaceutical compositions thereof; combinations uses thereof in treatment of, inter alia, conditions, diseases, symptoms including, Alzheimer's Disease, cancer, dementia, depression, diabetes, hair loss, schizophrenia, stroke.

参考文章(107)
David Thomas Parker, Lawrence J.. Macpherson, Arylsulfonamido-substituted hydroxamic acids ,(1993)
James W. Malecha, Thomas D. Penning, Ish K. Khanna, Matthew J. Graneto, Julie M. Miyashiro, Donald J. Rogier, Paul W. Collins, John J. Talley, Roland S. Rogers, Stephen R. Bertenshaw, Jeffery S. Carter, Substituted pyrazolyl benzenesulfonamides ,(1993)
Sadie Vile, Paul Barraclough, Alan Thomas Hudson, Karl Witold Franzmann, Ann Louise Walker, Stephen Carl Mckeown, Martin John Page, Tricyclic fused compounds and pharmaceutical compositions containing them ,(1996)
C. Richter King, Robert E. Bird, Philip G. Kasprzyk, Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof ,(1993)
James P. Rizzi, Anthony D. Piscopio, Arylsulfonyl hydroxamic acid derivatives as mmp and tnf inhibitors ,(1995)
Michiko Kosasa, Atsushi Sasaki, Yoshiharu Yamanishi, Hiroo Ogura, Takashi Kosasa, Shin Araki, Atsuhiko Kubota, Youichi Iimura, Norio Karibe, Kunizou Higurashi, Kiyomi Yamatsu, Hachiro Sugimoto, Yutaka Tsuchiya, Cyclic amine compounds with activity against acetylcholinesterase ,(1988)
Sarah E. Millar, Karl Willert, Patricia C. Salinas, Henk Roelink, Roel Nusse, Daniel J. Sussman, Gregory S. Barsh, WNT signaling in the control of hair growth and structure. Developmental Biology. ,vol. 207, pp. 133- 149 ,(1999) , 10.1006/DBIO.1998.9140