The acute and chronic effects of intravitreal anti-vascular endothelial growth factor injections on intraocular pressure: A review.

摘要: The acute and chronic effects of repeated intravitreal antivascular endothelial growth factor (VEGF) injections on intraocular pressure have not been fully characterized, the development sustained ocular hypertension could adversely affect patients who are at risk glaucomatous optic neuropathy. As expected, volume-driven, immediately follows injection, but this elevation is generally transient well tolerated. Several medications investigated to limit following anti-VEGF therapy, benefits pretreatment conclusive. Chronic, hypertension, distinct from short-term after each has also associated with injections. Risk factors for include total number injections, a greater frequency preexisting glaucoma. Proposed mechanisms microparticle obstruction, toxic or inflammatory trabecular meshwork, as alterations in outflow facility by agents. Although limiting therapy minimize both foregoing risks progression various macular diseases resulting permanent central vision loss. While definitive evidence damage retinal nerve fiber layer lacking, receiving should be monitored whom subsequently developed periodically changes optical coherence tomography static visual fields.