Acute and chronic effects of growth hormone on renal regulation of electrolyte and water homeostasis.

摘要: For decades, growth hormone (GH) has been known to influence electrolyte and water handling in humans animals. However, the molecular mechanisms underlying GH-induced anti-natriuretic anti-diuretic effects have remained elusive. This review will examine existing literature on renal following acute chronic GH-exposure. Renal responses GH differ models. Acute application of results a reduced urinary excretion, whereas are more diverse, as this state likely represents complex mixture primary secondary actions well compensatory mechanisms. During GH-exposure an initial sodium retaining often occurs, followed by normalization although extracellular volume expansion still persists. We recently described possible mechanism which acutely increases reabsorption, modulation kidney specific Na(+), K(+), 2Cl(-) co-transporter (NKCC2). The aim is investigate how regulation NKCC2 may be involved changes previously during GH. propose, that increase activity explain retention seen number studies. Moreover, prolonged now background stimulation NKCC2. Additionally, also promotes acidification, thus influencing acid/base handling. acidification partly compatible with activity. Finally, we available data hormonal systems affecting tubular transport