The presence of biofilm structures in atherosclerotic plaques of arteries from legs amputated as a complication of diabetic foot ulcers.
作者： D. E. Snow , J. Everett , G. Mayer , S. B. Cox , B. Miller
DOI: 10.12968/JOWC.2016.25.SUP2.S16
关键词: Amputation 、 In patient 、 Complication 、 Medicine 、 Inflammation 、 Pathology 、 Diabetic foot 、 Endothelial stem cell 、 Circulatory system 、 Biofilm
摘要: Objective Atherosclerosis, rather than microcirculatory impairment caused by endothelial cell dysfunction, is the main driver of circulatory compromise in patients with diabetic limbs. The presence atherosclerotic plaque at trifurcation a significant contributor to amputation legs. bacteria and other microorganisms has long been known, however, cause chronic inflammation role bacteria/viruses atherosclerosis have not studied detail. objective this study was clarify within plaques, determine if any and/or viruses are involved inflammatory pathway. Method This uses fluorescence microscopy in-situ hybridisation (FISH) identify components biofilm arteries. These tools also used individual bacteria, architectural spatial location atherosclerotic...
sci-hub.se 参考文章(35)
N Høiby, T Bjarnsholt, C Moser, GL Bassi, Tom Coenye, G Donelli, L Hall-Stoodley, Veronika Holá, C Imbert, K Kirketerp-Møller, D Lebeaux, A Oliver, AJ Ullmann, C Williams, ESCMID Study Group for Biofilms, Consulting External Expert Werner Zimmerli, None, ESCMID∗ guideline for the diagnosis and treatment of biofilm infections 2014 Clinical Microbiology and Infection. ,vol. 21, ,(2015) , 10.1016/J.CMI.2014.10.024
Pradeep K. Singh, Amy L. Schaefer, Matthew R. Parsek, Thomas O. Moninger, Michael J. Welsh, E. P. Greenberg, Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms Nature. ,vol. 407, pp. 762- 764 ,(2000) , 10.1038/35037627
C. Hayashi, C.V. Gudino, F.C. Gibson III, C.A. Genco, Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Molecular Oral Microbiology. ,vol. 25, pp. 305- 316 ,(2010) , 10.1111/J.2041-1014.2010.00582.X
A. Simon Lynch, Gregory T. Robertson, Bacterial and Fungal Biofilm Infections Annual Review of Medicine. ,vol. 59, pp. 415- 428 ,(2008) , 10.1146/ANNUREV.MED.59.110106.132000
Paula I. Watnick, Laetitia Houot, A Novel Role for Enzyme I of the Vibrio cholerae Phosphoenolpyruvate Phosphotransferase System in Regulation of Growth in a Biofilm Journal of Bacteriology. ,vol. 190, pp. 311- 320 ,(2008) , 10.1128/JB.01410-07
Trevor Dalton, Scot E. Dowd, Randall D. Wolcott, Yan Sun, Chase Watters, John A. Griswold, Kendra P. Rumbaugh, An In Vivo Polymicrobial Biofilm Wound Infection Model to Study Interspecies Interactions PLoS ONE. ,vol. 6, pp. e27317- ,(2011) , 10.1371/JOURNAL.PONE.0027317
Luanne Hall-Stoodley, Paul Stoodley, Evolving concepts in biofilm infections Cellular Microbiology. ,vol. 11, pp. 1034- 1043 ,(2009) , 10.1111/J.1462-5822.2009.01323.X
Ravi Jain, Richard Douglas, When and how should we treat biofilms in chronic sinusitis Current Opinion in Otolaryngology & Head and Neck Surgery. ,vol. 22, pp. 16- 21 ,(2014) , 10.1097/MOO.0000000000000010
J Christopher Post, N Luisa Hiller, Laura Nistico, Paul Stoodley, Garth D Ehrlich, The role of biofilms in otolaryngologic infections: update 2007. Current Opinion in Otolaryngology & Head and Neck Surgery. ,vol. 15, pp. 347- 351 ,(2007) , 10.1097/MOO.0B013E3282B97327
Timothy L. Kelly, Michael C. W. Lam, Michael O. Wolf, Carbohydrate-labeled fluorescent microparticles and their binding to lectins. Bioconjugate Chemistry. ,vol. 17, pp. 575- 578 ,(2006) , 10.1021/BC050339G