Endothelin in human congestive heart failure.
作者： C M Wei , A Lerman , R J Rodeheffer , C G McGregor , R R Brandt
关键词: Medicine 、 Endothelin receptor 、 Vasoconstriction 、 Heart failure 、 Internal medicine 、 Asymptomatic 、 Heart disease 、 Cardiology 、 Radioimmunoassay 、 Endothelins 、 Endothelin 1
摘要: BACKGROUNDAlthough recent investigations report the elevation of plasma endothelin (ET) in congestive heart failure (CHF), it remains unclear if this is that biologically active peptide ET-1 or its precursor big-ET. Furthermore, such associated with increased myocardial ET and molecular form from cardiac tissue altered ET. Last, to be established whether circulating at earliest stage CHF patients asymptomatic left ventricular dysfunction correlates magnitude dysfunction.METHODS AND RESULTSThe present study was designed investigate concentrations forms healthy subjects New York Heart Association (NYHA) class I through IV using radionuclide angiogram, biopsy, radioimmunoassay, gel permeation chromatography (GPC), immunohistochemical staining (IHCS). Plasma ...
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