Inhibition of Transforming Growth Factor-β Signaling Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Mice
作者： Ziad Mallat , Andrea Gojova , Carmen Marchiol-Fournigault , Bruno Esposito , Caroline Kamaté
关键词: Pathogenesis 、 Macrophage 、 Blood vessel 、 Cancer research 、 Proinflammatory cytokine 、 Cytokine 、 Inflammation 、 Transforming growth factor 、 Signal transduction 、 Immunology 、 Biology
摘要: Atherosclerosis is a disease of the arterial wall that seems to be tightly modulated by local inflammatory balance. Whereas large body evidence supports role for proinflammatory mediators in progression, understanding antiinflammatory component modulation plaque progression only at its beginning. TGF-beta1, -beta2, and -beta3 are cytokines/growth factors with broad activities on cells tissues cardiovascular system have been proposed play pathogenesis atherosclerosis. However, no study has examined direct TGF-beta development composition advanced atherosclerotic lesions. In present study, we show inhibition signaling using neutralizing anti-TGF-beta1, antibody accelerates lesions apoE-deficient mice. Moreover, favors increased decreased collagen content. These results identify major protective
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