URINE SCREENING FOR FLUNITRAZEPAM: APPLICABILITY OF EMIT IMMUNOASSAY
作者： Henning Mørland , Anne Smith-Kielland
DOI: 10.1093/CLINCHEM/43.7.1245
关键词: Urine 、 Premedication 、 Enzyme multiplied immunoassay technique 、 Anesthesia 、 Immunoassay 、 Pharmacology 、 Drug 、 Hypnotic 、 Flunitrazepam 、 Schedule I Substance 、 Medicine
摘要: Benzodiazepines are commonly abused drugs. Accordingly, urine specimens often screened for benzodiazepines as part of drug-testing programs. However, immunoassays have different detection limits regarding the and their metabolites. Some therapeutically effective in low doses, also making difficult. Flunitrazepam belongs to this potent group low-dosage benzodiazepines. The metabolites flunitrazepam reported react weakly with most (1). Therefore, more time-consuming chromatographic analyses carried out detect intake. In letter we report applicability Emit® immunoassay (Behring Diagnostics, San Jose, CA) a preliminary screening test flunitrazepam. described approach has proven be both labor- time-saving. Flunitrazepam is prescribed primarily hypnotic, but used some countries premedication general anesthesia. not an approved drug US. Recently, focus been placed on (designated Schedule I substance), or “Roofies,” popular abuse (2 …
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