Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery

作者: Charles Robb Flynn , Vance L. Albaugh , Steven Cai , Joyce Cheung-Flynn , Phillip E. Williams

DOI: 10.1038/NCOMMS8715

关键词: FGF15EndocrinologyDuodenumIleumJejunumSteatosisGallbladderMedicineGut floraSmall intestineInternal medicine

摘要: … in regulating energy metabolism and improving insulin … biliary diversion mouse model, we examined the metabolic benefits of bile acids as a function of the intestinal site of bile diversion…

参考文章(70)
Deng Ping Yin, Qiang Gao, Lian Li Ma, Wenwei Yan, Phillip E. Williams, Owen P. McGuinness, David H. Wasserman, Naji N. Abumrad, Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice Annals of Surgery. ,vol. 254, pp. 73- 82 ,(2011) , 10.1097/SLA.0B013E3182197035
Takaharu Maruyama, Yasuhisa Miyamoto, Takao Nakamura, Yoshitaka Tamai, Hiromasa Okada, Eiji Sugiyama, Tatsuji Nakamura, Hiraku Itadani, Kenichi Tanaka, Identification of membrane-type receptor for bile acids (M-BAR). Biochemical and Biophysical Research Communications. ,vol. 298, pp. 714- 719 ,(2002) , 10.1016/S0006-291X(02)02550-0
Folkert Kuipers, Vincent W. Bloks, Albert K. Groen, Beyond intestinal soap—bile acids in metabolic control Nature Reviews Endocrinology. ,vol. 10, pp. 488- 498 ,(2014) , 10.1038/NRENDO.2014.60
Niamh Keating, Stephen J. Keely, Bile acids in regulation of intestinal physiology Current Gastroenterology Reports. ,vol. 11, pp. 375- 382 ,(2009) , 10.1007/S11894-009-0057-8
M K Hofman, M Groenendijk, P J J H Verkuijlen, I J A M Jonkers, M F Mohrschladt, A H M Smelt, H M G Princen, Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals. European Journal of Human Genetics. ,vol. 12, pp. 935- 941 ,(2004) , 10.1038/SJ.EJHG.5201236
Dimitri J. Pournaras, Clare Glicksman, Royce P. Vincent, Shophia Kuganolipava, Jamie Alaghband-Zadeh, David Mahon, Jan H.R. Bekker, Mohammad A. Ghatei, Stephen R. Bloom, Julian R.F. Walters, Richard Welbourn, Carel W. le Roux, The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control Endocrinology. ,vol. 153, pp. 3613- 3619 ,(2012) , 10.1210/EN.2011-2145
Philippe Gérard, Metabolism of cholesterol and bile acids by the gut microbiota. Pathogenetics. ,vol. 3, pp. 14- 24 ,(2013) , 10.3390/PATHOGENS3010014
A B Bornstein, M Ehrhart-Bornstein, V Lamounier-Zepter, T Lohmann, T Wolf, S R Bornstein, J Graessler, Y Qin, H Zhong, J Zhang, J Licinio, M-L Wong, A Xu, T Chavakis, Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters Pharmacogenomics Journal. ,vol. 13, pp. 514- 522 ,(2013) , 10.1038/TPJ.2012.43
Thomas J Hardcastle, Krystyna A Kelly, baySeq: Empirical Bayesian methods for identifying differential expression in sequence count data BMC Bioinformatics. ,vol. 11, pp. 422- 422 ,(2010) , 10.1186/1471-2105-11-422
Rohit Kohli, Michelle Kirby, Kenneth D. R. Setchell, Pinky Jha, Kori Klustaitis, Laura A. Woollett, Paul T. Pfluger, William F. Balistreri, Patrick Tso, Ronald J. Jandacek, Stephen C. Woods, James E. Heubi, Matthias H. Tschoep, David A. D'Alessio, Noah F. Shroyer, Randy J. Seeley, Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 299, ,(2010) , 10.1152/AJPGI.00221.2010