Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients
作者： Mark Sausen , Jillian Phallen , Vilmos Adleff , Siân Jones , Rebecca J Leary
DOI: 10.1038/NCOMMS8686
关键词: Cancer therapy 、 DNA 、 Somatic cell 、 Genomics 、 Cancer research 、 Regulation of gene expression 、 Bioinformatics 、 Pancreatic cancer 、 Biology 、 Gene 、 Chromatin
摘要: Somatic mutations have been reported in pancreatic adenocarcinomas. Here, Sausen et al. identify further and find that the chromatin modifying gene, MLL, are associated with increased survival, presence of circulating tumour DNA serum patients is poor survival.
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