The physical and chemical stability of suspensions of sustained-release diclofenac microspheres

摘要: AbstractThe major challenge in liquid sustained-release oral suspensions is to minimize drug diffusion into the suspending medium and retain original properties of microparticles during storage. Diclofenac wax microspheres prepared by hydrophobic congealable disperse phase method were formulated as a sustained release suspension stored at three different temperatures (25, 37 45 °C) for 3 months, evaluate physical chemical stability suspended microspheres. Suspensions ambient both physically chemically stable, but higher temperatures, up °C, there was decrease due scaling melting on microsphere surface observed scanning electron microscopy. However, prolonged storage, 90 days, especially temperature became dominant factor causing an increase release. The diclofenac stable while plain drug...