Characterization of microsomal prostaglandin E synthase 1 inhibitors.

摘要: Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible terminal synthase in PGE2 biosynthesis by inflammatory and cancer cells. Clinical experimental data emphasize that mPGES-1 might be a valuable target, with improved selectivity safety compared to traditional NSAIDs or selective COX-2 inhibitors, the treatment of diseases, different types as well central symptoms elicited peripheral inflammation. Since first characterization mPGES-1, numbers publications on structure, pathogenic role inhibitor development have increased exponentially; however, there are currently no inhibitors available for clinical use. In this MiniReview, we focus recent advances activity, aim discuss effects targeting models vitro vivo.