Importance of proteasome-mediated proteolysis and alterations of the ubiquitin/proteasome pathway in cancer cells

摘要: Abstract Regulated proteolysis is involved in a broad range of biological processes such as cell cycle control, antigen presentation and regulation gene expression. In most cases studied to date, controlled protein degradation carried out by the 26S proteasome following ubiquitination target protein. The ubiquitin/proteasome pathway major intracellular non-lysosomal proteolytic mechanism progression, control Recent work reviewed here has shown that this often cancer-related deregulation can underlie oncogenic transformation, tumor escape from immune surveillance drug resistance.