High Progesterone Levels and Ciliary Dysfunction—A Possible Cause of Ectopic Pregnancy
作者： Yoav Paltieli , Izu Eibschitz , Genia Ziskind , Gonen Ohel , Michael Silbermann
关键词: Luteinizing hormone 、 Gonadotropin 、 Fallopian tube 、 Hormone 、 Oviduct 、 Follicle-stimulating hormone 、 Endocrinology 、 Menotropins 、 Incubation 、 Biology 、 Internal medicine
摘要: Objectives: To investigate the effects of different levels ofhormones on ciliary activity human oviducts and,consequently, to assess their possible role in tubalimplantation fertilized egg. Design: Fallopian tube epithelial samples were incubatedin media with addition Estradiol (E2), progesterone(P), menopausal gonadotropin (hMG), LH, or pureFSH (Metrodin) concentrations. The beatfrequency (CBF) was measured after 24 h incubation.Then exchanged without theaddition hormones and CBF again hlater by using photoelectric technique. Setting: University teaching hospital, IVF unit. Results: Twenty-four hr P culturemedium concentrations 0.5 1 ng/ml a significantdecline down 63% control level wasobserved (P < 0.001) concentration 2 greater, 50–70% cilia paralyzed. Theseeffects found be reversible. Incubation E2induced slight increase 4% mean =0.002). incubation Metrodin, Pergonal,or LH did not affect motility. Conclusions: Higher progesterone cause ciliarydysfunction subsequently may ofectopic pregnancy.
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