Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling

作者: G P Manjunath , Praveena L Ramanujam , Sanjeev Galande

DOI: 10.1007/S12038-017-9727-0

关键词: Computational biologyMultiple sequence alignmentPeptide bindingPlasma protein bindingPeptide sequenceScaffold proteinSequence alignmentConserved sequencePDZ domainChemistry

摘要: Protein scaffolds as essential backbones for organization of supramolecular signalling complexes are a recurrent theme in several model systems. Scaffold proteins preferentially employ linear peptide binding motifs recruiting their interaction partners. PDZ domains one the more commonly encountered including those involved scaffolding functions. This domain is known its promiscuity both terms ligand selection, mode with ligands well association other protein domains. subject to means regulations by virtue functional diversity. Additionally, refractive effect mutations and maintain three-dimensional architecture under extreme mutational load. The biochemical biophysical basis this selectivity has been investigated reviewed extensively. present review focuses on plasticity inherent implications modular evolution cellular pathways higher eukaryotes.

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