Protein homeostasis imprinting across evolution

摘要: Abstract The control of protein homeostasis (a.k.a. proteostasis) is associated with the primary functions life, and therefore evolution. However, it unclear how cellular proteostasis has evolved to adjust biogenesis needs environmental constraints. Herein, we describe an approach evaluate during evolution, show that network (PN) represents a reliable metric i) deconvolute life forms into Archaea, Bacteria Eukaryotes ii) assess evolution rates among species, without need for rRNA sequences. This method phylogenetic comparison relies on use semantic graphs PN complexity. stands as novel strategy taxonomic classification, based analysis 94 Eukaryotes, 250 93 Archaea genome A functional was used powerful tool echoes species It provides information about divergence indicates clades faster than others did. Phyla-specific were identified, suggesting complexity correlates grade have reached. Individual components, however, such heat shock proteins (HSP) do not accurately mark We analyzed gene conservation, gain or loss occurred throughout which reveals dichotomy within conserved parts (e.g. chaperones), but also species-specific modules. Since implicated in cell fitness, aging onset several diseases, could be tackle gain-of-functions mechanisms their biological impact.