Pharmacology of neuropeptide Y receptor antagonists. Focus on cardiovascular functions.

摘要: Neuropeptide Y is one of the most abundant mammalian neuropeptides identified to date. The possible actions neuropeptide Y, that co-localized and released with noradrenaline, as a sympathetic co-transmitter has attracted much attention during last decade. In recent years, several non-peptide antagonists high subtype selectivity for receptors have been introduced. With them, status transmitter established, so profound cardiovascular effects mediated by Y(1) Y(2) receptors. Significant release occurs especially upon stronger activation, data suggest importance seems enhanced in stress-related disorders. true significance thus started unfold, owing presence first generation selective receptor antagonists. This review concerns pharmacology these agents, what we learnt from might find out future.