The Expression of Presenilin-1 mRNA in Skin Fibroblasts from Alzheimer’s Disease

作者: Kazuyuki Ikeda , Katsuya Urakami , Kenji Isoe , Kousaku Ohno , Kenji Nakashima

DOI: 10.1159/000017039

关键词: Messenger RNAGene expressionGeneDegenerative diseaseDiseaseNorthern blotPresenilinAlzheimer's diseaseBiologyImmunology

摘要: The presenilin-1 (PS-1) gene was recently identified as one of the causative genes in early onset familial Alzheimer’s disease (AD). Analysis PS-1 is thought to be useful clarify

参考文章(27)
Joab Chapman, Alexander Asherov, Ningshan Wang, ThereseA. Treves, AmosD. Korczyn, LevG. Goldfarb, Familial Alzheimer's disease associated with S182 codon 286 mutation The Lancet. ,vol. 346, pp. 1040- ,(1995) , 10.1016/S0140-6736(95)91723-3
K. Boteva, M. Vitek, H. Mitsuda, Har de Silva, P-T. Xu, G. Small, J.R. Gilbert, Mutation analysis of presenilin 1 gene in Alzheimer's disease The Lancet. ,vol. 347, pp. 130- 131 ,(1996) , 10.1016/S0140-6736(96)90261-5
Hiroshi Tanahashi, Yoshihiro Mitsunaga, Keikichi Takahashi, Hirokazu Tasaki, Shunzo Watanabe, Takeshi Tabira, Missense mutation of S182 gene in Japanese familial Alzheimer's disease The Lancet. ,vol. 346, pp. 440- ,(1995) , 10.1016/S0140-6736(95)92810-3
Akira Ueki, Mikihiko Kawano, Yoshio Namba, Masanobu Kawakami, Kazuhiko Ikeda, A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease Neuroscience Letters. ,vol. 163, pp. 166- 168 ,(1993) , 10.1016/0304-3940(93)90373-S
K. Isoe, K. Urakami, Y. Ji, Y. Adachi, K. Nakashima, Presenilin‐1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol‐associated dementia in Japanese population Acta Neurologica Scandinavica. ,vol. 94, pp. 326- 328 ,(1996) , 10.1111/J.1600-0404.1996.TB07074.X
M.N. Rossor, N.C. Fox, J. Beck, T.C. Campbell, J. Collinge, Incomplete penetrance of familial Alzheimer's disease in a pedigree with a novel presenilin-1 gene mutation The Lancet. ,vol. 347, pp. 1560- ,(1996) , 10.1016/S0140-6736(96)90715-1
Tae-Wan Kim, Rudolph E Tanzi, Presenilins and Alzheimer's disease Current Opinion in Neurobiology. ,vol. 7, pp. 683- 688 ,(1997) , 10.1016/S0959-4388(97)80089-X
Piotr Chomczynski, Nicoletta Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Analytical Biochemistry. ,vol. 162, pp. 156- 159 ,(1987) , 10.1016/0003-2697(87)90021-2
Michelle Wragg, C Talbot, M Hutton, Alison Goate, Alzheimer's Disease Collaborative Group, None, Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease The Lancet. ,vol. 347, pp. 509- 512 ,(1996) , 10.1016/S0140-6736(96)91140-X