pH-dependent nanodiamonds enhance the mechanical properties of 3D-printed hyaluronic acid nanocomposite hydrogels

摘要: Nanocomposite hydrogels capable of undergoing manufacturing process have recently attracted attention in biomedical applications due to their desired mechanical properties and high functionality. 3D printing nanocomposite hyaluronic acid (HA)/nanodiamond (ND) revealed that the addition ND with low weight ratio 0.02 wt% resulted higher compressive force gel breaking point, compared HA only nanocomposites. These loaded surface functionalized allowed for enforced stress be tuned a pH-dependent manner. ND-OH at pH 8 showed an increase 1.40-fold (0.02%: 236.18 kPa) 1.37-fold (0.04%: 616.72 kPa) composition 0.04 wt, respectively, those ND-COOH 168.31 kPa, 0.04%: 449.59 kPa) same pH. Moreover, HA/ND-OH (0.04 wt%) was mechanically enhanced 1.29-fold, 7. results indicate tunable buffering environment interaction long chains molecular level critical role dependency on Due stability nanophase, filament-based processing layer-based deposition microscale attained hydrogel. Fine tuning inorganic nanophase controlled leads improved control over reported herein.