Attitudinal barriers to participation in oncology clinical trials: factor analysis and correlates of barriers

摘要: Patient participation in cancer clinical trials is low. Little known about attitudinal barriers to participation, particularly among patients who may be offered a trial during an imminent initial oncology consult. The aims of the present study were confirm presence proposed subscales recently developed measure, describe most common barriers, and evaluate socio-demographic, medical financial factors associated with barriers. A total 1256 completed survey assessing demographic factors, perceived burden, prior participation. Results factor analysis did not four subscale/factors. Rather, single represented best fit data. highly-rated fear side-effects, worry health insurance efficacy concerns. suggested that less educated patients, non-metastatic disease, no previous reporting greater burden from care higher These need extra attention terms decisional support. Overall, fewer personal resources (education, issues) report more should targeted for additional