Drosophila Matrix Metalloproteinases Are Required for Tissue Remodeling, but Not Embryonic Development
作者： Andrea Page-McCaw , Julia Serano , Joshua M. Santé , Gerald M. Rubin
DOI: 10.1016/S1534-5807(02)00400-8
关键词: Biology 、 Drosophila melanogaster 、 Matrix metalloproteinase 、 MMP2 、 Embryogenesis 、 Genetics 、 Cell biology 、 Mutant 、 Embryo 、 MMP1 、 Histolysis
摘要: The matrix metalloproteinase (MMP) family is heavily implicated in many diseases, including cancer. developmental functions of these genes are not clear, however, because the >20 mammalian MMPs can be functionally redundant. Drosophila melanogaster has only two MMPs, which expressed embryos distinct patterns. We created mutations both genes: Mmp1 mutants have defects larval tracheal growth and pupal head eversion, Mmp2 tissue histolysis epithelial fusion during metamorphosis; neither required for embryonic development. Double also complete embryogenesis, represent first time, to our knowledge, that all been disrupted any organism. Thus, development, but, rather, remodeling.
elsevier.com
sci-hub.se 参考文章(40)
Tanja A. Godenschwege, Natascha Pohar, Sigrid Buchner, Erich Buchner, Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila. European Journal of Cell Biology. ,vol. 79, pp. 495- 501 ,(2000) , 10.1078/0171-9335-00072
Franz-Xaver Gomis-R¨th, Klaus Maskos, Michael Betz, Andreas Bergner, Robert Huber, Ko Suzuki, Naoki Yoshida, Hideaki Nagase, Keith Brew, Gleb P. Bourenkov, Hans Bartunik, Wolfram Bode, Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature. ,vol. 389, pp. 77- 81 ,(1997) , 10.1038/37995
Norbert Perrimon, Tze-bin Chou, The Autosomal FLP-DFS Technique for Generating Germline Mosaics in Drosophila melanogaster Genetics. ,vol. 144, pp. 1673- 1679 ,(1996) , 10.1093/GENETICS/144.4.1673
Zena Werb, Farrah Kheradmand, Kirtee Rishi, Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2 Journal of Cell Science. ,vol. 115, pp. 839- 848 ,(2002) , 10.1242/JCS.115.4.839
Z. Zhou, S. S. Apte, R. Soininen, R. Cao, G. Y. Baaklini, R. W. Rauser, J. Wang, Y. Cao, K. Tryggvason, Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 4052- 4057 ,(2000) , 10.1073/PNAS.060037197
Jill M. Maidment, Darren Moore, George P. Murphy, Gillian Murphy, Ian M. Clark, Matrix metalloproteinase homologues from Arabidopsis thaliana. Expression and activity. Journal of Biological Chemistry. ,vol. 274, pp. 34706- 34710 ,(1999) , 10.1074/JBC.274.49.34706
J. Gross, C. M. Lapiere, COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY Proceedings of the National Academy of Sciences. ,vol. 48, pp. 1014- 1022 ,(1962) , 10.1073/PNAS.48.6.1014
C. C. Kopczynski, J. N. Noordermeer, T. L. Serano, W.-Y. Chen, J. D. Pendleton, S. Lewis, C. S. Goodman, G. M. Rubin, A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 9973- 9978 ,(1998) , 10.1073/PNAS.95.17.9973
Mikala Egeblad, Zena Werb, New functions for the matrix metalloproteinases in cancer progression Nature Reviews Cancer. ,vol. 2, pp. 161- 174 ,(2002) , 10.1038/NRC745
Elena Llano, Geza Adam, Alberto M. Pendás, Vı́ctor Quesada, Luis M. Sánchez, Iñigo Santamarı́a, Stéphane Noselli, Carlos López-Otı́n, Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. Journal of Biological Chemistry. ,vol. 277, pp. 23321- 23329 ,(2002) , 10.1074/JBC.M200121200