Compounds for the treatment of peripheral neuropathies

摘要: A compound of formula A1 or A2 for use in the treatment a demyelinating peripheral neuropathy: wherein is COOR 5 , OPO(OR ) 2 PO(OR SO OR POR 1 H -tetrazol-5-yl, R being an ester-forming group, optionally C 1-6 alkyl; W bond, 1-3 alkylene 2-3 alkenylene; Y 6-10 aryl 2-9 heteroaryl eg 3-9 heteroaryl, substituted by to 3 radicals selected from halogen, OH, NO alkyl, alkoxy; halo-substituted alkyl and Z chosen Formula (I) : asterisks indicate point attachment between -C(R )(R 4 )- (Ia) (Ib), respectively; 6 hydrogen J are independently methylene heteroatom S, O NR ; any can be further one three halo, hydroxy, attached carbon atom form 5-7 member ring; aryl, arylC 1-4 heteroarylC 3-8 cycloalkyl, cycloalkylC heterocycloalkyl heterocycloalkylC cycloalkyl may groups alkoxy halo substituted-C -C H, 2-6 alkenyl alkynyl; each independently, N-oxide derivatives thereof prodrugs thereof, pharmacologically acceptable salt, solvate hydrate thereof.