The Organization of Genomic DNA in Mitotic Chromosomes: A Novel View

摘要: In 1878, W. Flemming discovered a nuclear substance that was visible on staining under the light microscope and named it ‘chromatin’, which is basic unit of genomic DNA organisation. During cell division, chromatin forms into microscopic bodies, called ‘chromosomes’, ensures transmission duplicated DNA. The term ‘chromosome’ derived from Greek for ‘coloured body’, reflecting observation condensed chromosome clearly with dyes. Long before discovery as genetic material, mitotic has fascinated biologists being candidate structure involved in heredity. therefore expected to be well conserved among eukaryotes, although some minor differences may found between different groups organisms. this chapter, we provide new insight an historical background: available evidence suggests chromosomes essentially consist irregularly-folded nucleosome fibers (beads-on-a-string) without 30-nm fiber. We also discuss structural plant mammalian chromatin.