Multi-well microfiltration apparatus

摘要: The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including: (i) plate having an array minicolumns into placed; (ii) discrete filter element disposed each minicolumn; (iii) drip-director corresponding drip directors through filtrate may egress; (iv) receiving-well receiving wells flow. arrangements that are relatively simple to manufacture overcome many problems associated with prior relating to: cross-contamination due wicking across common sheet or individual elements entrapping sample constituents within substantial dead volumes. Further, adequately support without creating preferential Additionally, avoid aerosol formation, pendant drops splattering. Other disclosed features provide for automated covering heat-sealing separately collected wells.