Anti-tumor gene therapy.
作者： C. Cirielli , M.C. Capogrossi , A. Passaniti
关键词: Primary tumor 、 Immunology 、 Thymidine kinase 、 Expression vector 、 Genetic enhancement 、 Gene 、 Melanoma 、 Retrovirus 、 Cancer research 、 Biology 、 Suppressor
摘要: Gene therapy as an anti-tumor strategy is becoming a powerful tool for cytokine delivery to inhibit the growth of many tumors. Several systems are being utilized and designed expression specific genes achieve therapeutic result. Liposomes, retroviral vectors, adenoviral vectors have all been used eventual clinical application may depend on type tumor, location, gene carried, patient‘s health status. Novel eventually tissue-specific targeting low immuno-reactivity. Inactivation mutated oncogenes, such ras, or re-expression inactive suppressor genes, p53 strategies therapy. Additionally, exogenous su ch viral thymidine kinase that metabolize chemotherapeutic agents local cytotoxicity also employed. Neuro-endocrine tumors targets these genetic since they often difficult treat by conventional methods bec ause their location (brain tumors) because spread from primary tumor (melanoma). Further advances in design safe variety malignant
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